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High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma.
Garcha HK, Nawar N, Sorger H, Erdogan F, Aung MMK, Sedighi A, Manaswiyoungkul P, Seo HS, Schönefeldt S, Pölöske D, Dhe-Paganon S, Neubauer HA, Mustjoki SM, Herling M, de Araujo ED, Moriggl R, Gunning PT. Garcha HK, et al. Among authors: mustjoki sm. Pharmaceuticals (Basel). 2022 Oct 26;15(11):1321. doi: 10.3390/ph15111321. Pharmaceuticals (Basel). 2022. PMID: 36355493 Free PMC article.
STAT3 Mutation Is Associated with STAT3 Activation in CD30+ ALK- ALCL.
Andersson EI, Brück O, Braun T, Mannisto S, Saikko L, Lagström S, Ellonen P, Leppä S, Herling M, Kovanen PE, Mustjoki S. Andersson EI, et al. Cancers (Basel). 2020 Mar 16;12(3):702. doi: 10.3390/cancers12030702. Cancers (Basel). 2020. PMID: 32188095 Free PMC article.
Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia.
Toutah K, Nawar N, Timonen S, Sorger H, Raouf YS, Bukhari S, von Jan J, Ianevski A, Gawel JM, Olaoye OO, Geletu M, Abdeldayem A, Israelian J, Radu TB, Sedighi A, Bhatti MN, Hassan MM, Manaswiyoungkul P, Shouksmith AE, Neubauer HA, de Araujo ED, Aittokallio T, Krämer OH, Moriggl R, Mustjoki S, Herling M, Gunning PT. Toutah K, et al. J Med Chem. 2021 Jun 24;64(12):8486-8509. doi: 10.1021/acs.jmedchem.1c00420. Epub 2021 Jun 8. J Med Chem. 2021. PMID: 34101461 Free PMC article.
Structural and mutational analysis of member-specific STAT functions.
Erdogan F, Qadree AK, Radu TB, Orlova A, de Araujo ED, Israelian J, Valent P, Mustjoki SM, Herling M, Moriggl R, Gunning PT. Erdogan F, et al. Among authors: mustjoki sm. Biochim Biophys Acta Gen Subj. 2022 Mar;1866(3):130058. doi: 10.1016/j.bbagen.2021.130058. Epub 2021 Nov 11. Biochim Biophys Acta Gen Subj. 2022. PMID: 34774983 Review.
JAK-STAT core cancer pathway: An integrative cancer interactome analysis.
Erdogan F, Radu TB, Orlova A, Qadree AK, de Araujo ED, Israelian J, Valent P, Mustjoki SM, Herling M, Moriggl R, Gunning PT. Erdogan F, et al. Among authors: mustjoki sm. J Cell Mol Med. 2022 Apr;26(7):2049-2062. doi: 10.1111/jcmm.17228. Epub 2022 Mar 1. J Cell Mol Med. 2022. PMID: 35229974 Free PMC article. Review.
Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.
Suske T, Sorger H, Manhart G, Ruge F, Prutsch N, Zimmerman MW, Eder T, Abdallah DI, Maurer B, Wagner C, Schönefeldt S, Spirk K, Pichler A, Pemovska T, Schweicker C, Pölöske D, Hubanic E, Jungherz D, Müller TA, Aung MMK, Orlova A, Pham HTT, Zimmel K, Krausgruber T, Bock C, Müller M, Dahlhoff M, Boersma A, Rülicke T, Fleck R, de Araujo ED, Gunning PT, Aittokallio T, Mustjoki S, Sanda T, Hartmann S, Grebien F, Hoermann G, Haferlach T, Staber PB, Neubauer HA, Look AT, Herling M, Moriggl R. Suske T, et al. J Clin Invest. 2024 Apr 15;134(8):e168536. doi: 10.1172/JCI168536. J Clin Invest. 2024. PMID: 38618957 Free PMC article.
Optimizing drug combinations for T-PLL: restoring DNA damage and P53-mediated apoptotic responses.
von Jan J, Timonen S, Braun T, Jiang Q, Ianevski A, Peng Y, McConnell K, Sindaco P, Müller TA, Pützer S, Klepzig H, Jungherz D, Dechow A, Wahnschaffe L, Giri AK, Kankainen M, Kuusanmäki H, Neubauer HA, Moriggl R, Mazzeo P, Schmidt N, Koch R, Hallek M, Chebel A, Armisen D, Genestier L, Bachy E, Mishra A, Schrader A, Aittokallio T, Mustjoki S, Herling M. von Jan J, et al. Blood. 2024 Oct 10;144(15):1595-1610. doi: 10.1182/blood.2023022884. Blood. 2024. PMID: 38941598
158 results