Lau CH - Search Results

1

Multimodal detection of flap endonuclease 1 activity through CRISPR/Cas12a trans-cleavage of single-strand DNA oligonucleotides.

Cui C, Lau CH, Chu LT, Kwong HK, Tin C, Chen TH. Cui C, et al. Among authors: lau ch. Biosens Bioelectron. 2023 Jan 15;220:114859. doi: 10.1016/j.bios.2022.114859. Epub 2022 Oct 31. Biosens Bioelectron. 2023. PMID: 36368142

2

Targeted Transgene Activation in the Brain Tissue by Systemic Delivery of Engineered AAV1 Expressing CRISPRa.

Lau CH, Ho JW, Lo PK, Tin C. Lau CH, et al. Mol Ther Nucleic Acids. 2019 Jun 7;16:637-649. doi: 10.1016/j.omtn.2019.04.015. Epub 2019 Apr 23. Mol Ther Nucleic Acids. 2019. PMID: 31108320 Free PMC article.

3

The Synergy between CRISPR and Chemical Engineering.

Lau CH, Tin C. Lau CH, et al. Curr Gene Ther. 2019;19(3):147-171. doi: 10.2174/1566523219666190701100556. Curr Gene Ther. 2019. PMID: 31267870 Review.

4

Synthetic α-l-Threose Nucleic Acids Targeting BcL-2 Show Gene Silencing and in Vivo Antitumor Activity for Cancer Therapy.

Wang F, Liu LS, Lau CH, Han Chang TJ, Tam DY, Leung HM, Tin C, Lo PK. Wang F, et al. Among authors: lau ch. ACS Appl Mater Interfaces. 2019 Oct 23;11(42):38510-38518. doi: 10.1021/acsami.9b14324. Epub 2019 Oct 8. ACS Appl Mater Interfaces. 2019. PMID: 31556592

5

Penetrating the Blood-Brain Barrier by Self-Assembled 3D DNA Nanocages as Drug Delivery Vehicles for Brain Cancer Therapy.

Tam DY, Ho JW, Chan MS, Lau CH, Chang TJH, Leung HM, Liu LS, Wang F, Chan LLH, Tin C, Lo PK. Tam DY, et al. Among authors: lau ch. ACS Appl Mater Interfaces. 2020 Jul 1;12(26):28928-28940. doi: 10.1021/acsami.0c02957. Epub 2020 Jun 19. ACS Appl Mater Interfaces. 2020. PMID: 32432847

6

Targeted brain tumor imaging by using discrete biopolymer-coated nanodiamonds across the blood-brain barrier.

Leung HM , Lau CH , Ho JW , Chan MS , Chang TJH , Law LH , Wang F , Tam DY , Liu LS , Chan KWY , Tin C , Lo PK . Leung HM , et al. Among authors: lau ch. Nanoscale. 2021 Feb 7;13(5):3184-3193. doi: 10.1039/d0nr06765b. Epub 2021 Feb 2. Nanoscale. 2021. PMID: 33527933

7

CRISPR-based strategies for targeted transgene knock-in and gene correction.

Lau CH, Tin C, Suh Y. Lau CH, et al. Fac Rev. 2020 Dec 4;9:20. doi: 10.12703/r/9-20. eCollection 2020. Fac Rev. 2020. PMID: 33659952 Free PMC article. Review.

8

Cellular uptake, tissue penetration, biodistribution, and biosafety of threose nucleic acids: Assessing in vitro and in vivo delivery.

Wang F, Liu LS, Li P, Lau CH, Leung HM, Chin YR, Tin C, Lo PK. Wang F, et al. Among authors: lau ch. Mater Today Bio. 2022 May 18;15:100299. doi: 10.1016/j.mtbio.2022.100299. eCollection 2022 Jun. Mater Today Bio. 2022. PMID: 35637854 Free PMC article.

9

PAM-flexible dual base editor-mediated random mutagenesis and self-activation strategies to improve CRISPRa potency.

Lau CH, Huang S, Lam RHW, Tin C. Lau CH, et al. Mol Ther Methods Clin Dev. 2022 May 29;26:26-37. doi: 10.1016/j.omtm.2022.05.005. eCollection 2022 Sep 8. Mol Ther Methods Clin Dev. 2022. PMID: 35755943 Free PMC article.

10

Extended replicative lifespan of primary resting T cells by CRISPR/dCas9-based epigenetic modifiers and transcriptional activators.

Huang S, Lau CH, Tin C, Lam RHW. Huang S, et al. Among authors: lau ch. Cell Mol Life Sci. 2024 Sep 17;81(1):407. doi: 10.1007/s00018-024-05415-9. Cell Mol Life Sci. 2024. PMID: 39287670 Free PMC article.

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