Guhathakurta P - Search Results

1

Enhancing interaction of actin and actin-binding domain 1 of dystrophin with modulators: Toward improved gene therapy for Duchenne muscular dystrophy.

Guhathakurta P, Carter AL, Thompson AR, Kurila D, LaFrence J, Zhang L, Trask JR, Vanderheyden B, Muretta JM, Ervasti JM, Thomas DD. Guhathakurta P, et al. J Biol Chem. 2022 Dec;298(12):102675. doi: 10.1016/j.jbc.2022.102675. Epub 2022 Nov 11. J Biol Chem. 2022. PMID: 36372234 Free PMC article.

2

Allosteric communication in Dictyostelium myosin II.

Guhathakurta P, Prochniewicz E, Muretta JM, Titus MA, Thomas DD. Guhathakurta P, et al. J Muscle Res Cell Motil. 2012 Oct;33(5):305-12. doi: 10.1007/s10974-012-9304-y. Epub 2012 Jul 1. J Muscle Res Cell Motil. 2012. PMID: 22752265 Free PMC article.

3

The structural dynamics of actin during active interaction with myosin depends on the isoform of the essential light chain.

Prochniewicz E, Guhathakurta P, Thomas DD. Prochniewicz E, et al. Among authors: guhathakurta p. Biochemistry. 2013 Mar 5;52(9):1622-30. doi: 10.1021/bi3014467. Epub 2013 Feb 15. Biochemistry. 2013. PMID: 23339370 Free PMC article.

4

Amplitude of the actomyosin power stroke depends strongly on the isoform of the myosin essential light chain.

Guhathakurta P, Prochniewicz E, Thomas DD. Guhathakurta P, et al. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4660-5. doi: 10.1073/pnas.1420101112. Epub 2015 Mar 30. Proc Natl Acad Sci U S A. 2015. PMID: 25825773 Free PMC article.

5

A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure.

Guhathakurta P, Prochniewicz E, Roopnarine O, Rohde JA, Thomas DD. Guhathakurta P, et al. Biophys J. 2017 Jul 11;113(1):91-100. doi: 10.1016/j.bpj.2017.05.027. Biophys J. 2017. PMID: 28700929 Free PMC article.

6

High-throughput screen, using time-resolved FRET, yields actin-binding compounds that modulate actin-myosin structure and function.

Guhathakurta P, Prochniewicz E, Grant BD, Peterson KC, Thomas DD. Guhathakurta P, et al. J Biol Chem. 2018 Aug 3;293(31):12288-12298. doi: 10.1074/jbc.RA118.002702. Epub 2018 Jun 4. J Biol Chem. 2018. PMID: 29866882 Free PMC article.

7

Actin-Myosin Interaction: Structure, Function and Drug Discovery.

Guhathakurta P, Prochniewicz E, Thomas DD. Guhathakurta P, et al. Int J Mol Sci. 2018 Sep 5;19(9):2628. doi: 10.3390/ijms19092628. Int J Mol Sci. 2018. PMID: 30189615 Free PMC article. Review.

8

Actin-binding compounds, previously discovered by FRET-based high-throughput screening, differentially affect skeletal and cardiac muscle.

Guhathakurta P, Phung LA, Prochniewicz E, Lichtenberger S, Wilson A, Thomas DD. Guhathakurta P, et al. J Biol Chem. 2020 Oct 9;295(41):14100-14110. doi: 10.1074/jbc.RA120.014445. Epub 2020 Aug 11. J Biol Chem. 2020. PMID: 32788211 Free PMC article.

9

Novel drug discovery platform for spinocerebellar ataxia, using fluorescence technology targeting β-III-spectrin.

Rebbeck RT, Andrick AK, Denha SA, Svensson B, Guhathakurta P, Thomas DD, Hays TS, Avery AW. Rebbeck RT, et al. Among authors: guhathakurta p. J Biol Chem. 2021 Jan-Jun;296:100215. doi: 10.1074/jbc.RA120.015417. Epub 2020 Dec 24. J Biol Chem. 2021. PMID: 33839680 Free PMC article.

10

Cardiac myosin-binding protein C interaction with actin is inhibited by compounds identified in a high-throughput fluorescence lifetime screen.

Bunch TA, Guhathakurta P, Lepak VC, Thompson AR, Kanassatega RS, Wilson A, Thomas DD, Colson BA. Bunch TA, et al. Among authors: guhathakurta p. J Biol Chem. 2021 Jul;297(1):100840. doi: 10.1016/j.jbc.2021.100840. Epub 2021 May 28. J Biol Chem. 2021. PMID: 34052227 Free PMC article.

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