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Discovery of 5,7-Dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones as Highly Selective CDK2 Inhibitors.
Sokolsky A, Winterton S, Kennedy K, Drake K, Stump K, Huo L, Lo Y, Ye M, Covington M, Diamond S, Yang YO, Kim S, Yeleswaram S, Wu L, Yao W. Sokolsky A, et al. Among authors: yang yo. ACS Med Chem Lett. 2022 Oct 6;13(11):1797-1804. doi: 10.1021/acsmedchemlett.2c00408. eCollection 2022 Nov 10. ACS Med Chem Lett. 2022. PMID: 36385925 Free PMC article.
Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor.
Koblish HK, Wu L, Wang LS, Liu PCC, Wynn R, Rios-Doria J, Spitz S, Liu H, Volgina A, Zolotarjova N, Kapilashrami K, Behshad E, Covington M, Yang YO, Li J, Diamond S, Soloviev M, O'Hayer K, Rubin S, Kanellopoulou C, Yang G, Rupar M, DiMatteo D, Lin L, Stevens C, Zhang Y, Thekkat P, Geschwindt R, Marando C, Yeleswaram S, Jackson J, Scherle P, Huber R, Yao W, Hollis G. Koblish HK, et al. Among authors: yang yo, yang g. Cancer Discov. 2022 Jun 2;12(6):1482-1499. doi: 10.1158/2159-8290.CD-21-1156. Cancer Discov. 2022. PMID: 35254416 Free PMC article. Clinical Trial.
Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2.
Nguyen MH, Atasoylu O, Wu L, Kapilashrami K, Pusey M, Gallagher K, Lai CT, Zhao P, Barbosa J, Liu K, He C, Zhang C, Styduhar ED, Witten MR, Chen Y, Lin L, Yang YO, Covington M, Diamond S, Yeleswaram S, Yao W. Nguyen MH, et al. Among authors: yang yo. ACS Med Chem Lett. 2022 Jun 22;13(7):1159-1164. doi: 10.1021/acsmedchemlett.2c00206. eCollection 2022 Jul 14. ACS Med Chem Lett. 2022. PMID: 35859885 Free PMC article.
Selective targeting of mutated calreticulin by the monoclonal antibody INCA033989 inhibits oncogenic function of MPN.
Reis ES, Buonpane R, Celik H, Marty C, Lei A, Jobe F, Rupar M, Zhang Y, DiMatteo D, Awdew R, Ferreira BL, Leffet L, Lu L, Rosa E, Evrard M, Trivedi G, Wass B, Horsey A, He X, Covington M, Volgina A, Pasquier F, Legros L, Fouquet G, Vainchenker W, Yang YO, Barker B, Zhou J, Stewart S, Hitchcock IS, Dhanak D, Macarron R, Plo I, Nastri H, Mayes PA. Reis ES, et al. Among authors: yang yo. Blood. 2024 Nov 28;144(22):2336-2348. doi: 10.1182/blood.2024024373. Blood. 2024. PMID: 39255409 Free article.
Itacitinib (INCB039110), a JAK1 Inhibitor, Reduces Cytokines Associated with Cytokine Release Syndrome Induced by CAR T-cell Therapy.
Huarte E, O'Connor RS, Peel MT, Nunez-Cruz S, Leferovich J, Juvekar A, Yang YO, Truong L, Huang T, Naim A, Milone MC, Smith PA. Huarte E, et al. Among authors: yang yo. Clin Cancer Res. 2020 Dec 1;26(23):6299-6309. doi: 10.1158/1078-0432.CCR-20-1739. Epub 2020 Sep 30. Clin Cancer Res. 2020. PMID: 32998963 Free PMC article.
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