Bednarski PJ - Search Results

1

Replacing the oxidation-sensitive triaminoaryl chemotype of problematic K_V 7 channel openers: Exploration of a nicotinamide scaffold.

Wurm KW, Bartz FM, Schulig L, Bodtke A, Bednarski PJ, Link A. Wurm KW, et al. Among authors: bednarski pj. Arch Pharm (Weinheim). 2023 Feb;356(2):e2200473. doi: 10.1002/ardp.202200473. Epub 2022 Nov 17. Arch Pharm (Weinheim). 2023. PMID: 36395379

2

Structure-Activity Relationships of Flupirtine Analogues for Liver Esterase-Mediated Cleavage of the 4-Fluorobenzylamine Moiety and Its Possible Relevance to Liver Toxicity.

Beirow K, Jedamzik J, Schulig L, Wurm KW, Lemmerhirt CJ, Hofstetter RK, Link A, Bednarski PJ. Beirow K, et al. Among authors: bednarski pj. ChemMedChem. 2023 Jul 17;18(14):e202300145. doi: 10.1002/cmdc.202300145. Epub 2023 May 31. ChemMedChem. 2023. PMID: 37170841

3

Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety.

Surur AS, Chan CF, Bartz FM, Wong ILK, Nguyen VTD, Schulig L, Link A, Chan TH, Chow LMC, Bednarski PJ. Surur AS, et al. Among authors: bednarski pj. RSC Med Chem. 2024 Aug 30;15(11):3837-52. doi: 10.1039/d4md00426d. Online ahead of print. RSC Med Chem. 2024. PMID: 39297060 Free article.

4

Copper(II) Complexes with 1-(Isoquinolin-3-yl)heteroalkyl-2-ones: Synthesis, Structure and Evaluation of Anticancer, Antimicrobial and Antioxidant Potential.

Balewski Ł, Plech T, Korona-Głowniak I, Hering A, Szczesio M, Olczak A, Bednarski PJ, Kokoszka J, Kornicka A. Balewski Ł, et al. Among authors: bednarski pj. Int J Mol Sci. 2023 Dec 19;25(1):8. doi: 10.3390/ijms25010008. Int J Mol Sci. 2023. PMID: 38203181 Free PMC article.

5

Investigation of TGF-α-overexpressing mouse hepatocytes (TAMH) cultured as spheroids for use in hepatotoxicity screening of drug candidates.

Beirow K, Schmidt C, Jürgen B, Schlüter R, Schweder T, Bednarski PJ. Beirow K, et al. Among authors: bednarski pj. J Appl Toxicol. 2024 Feb;44(2):272-286. doi: 10.1002/jat.4538. Epub 2023 Sep 1. J Appl Toxicol. 2024. PMID: 37655636

6

Liposomal formulation of model pentathiepin improves solubility and stability toward glutathione while preserving anticancer activity.

Napierkowski M, Janke U, Rong A, Delcea M, Bandaru SSM, Schulzke C, Bednarski PJ. Napierkowski M, et al. Among authors: bednarski pj. Arch Pharm (Weinheim). 2023 Oct;356(10):e2300087. doi: 10.1002/ardp.202300087. Epub 2023 Jul 28. Arch Pharm (Weinheim). 2023. PMID: 37507825

7

A graphite furnace-atomic absorption spectrometry-based rubidium efflux assay for screening activators of the K_v 7.2/3 channel.

Bartz FM, Beirow K, Wurm K, Baecker D, Link A, Bednarski PJ. Bartz FM, et al. Among authors: bednarski pj. Arch Pharm (Weinheim). 2023 May;356(5):e2200585. doi: 10.1002/ardp.202200585. Epub 2023 Feb 7. Arch Pharm (Weinheim). 2023. PMID: 36748851

8

Synthesis, Structure and Cytotoxic Properties of Copper(II) Complexes of 2-Iminocoumarins Bearing a 1,3,5-Triazine or Benzoxazole/Benzothiazole Moiety.

Makowska A, Sączewski F, Bednarski PJ, Gdaniec M, Balewski Ł, Warmbier M, Kornicka A. Makowska A, et al. Among authors: bednarski pj. Molecules. 2022 Oct 22;27(21):7155. doi: 10.3390/molecules27217155. Molecules. 2022. PMID: 36363982 Free PMC article.

9

Carba Analogues of Flupirtine and Retigabine with Improved Oxidation Resistance and Reduced Risk of Quinoid Metabolite Formation.

Wurm KW, Bartz FM, Schulig L, Bodtke A, Bednarski PJ, Link A. Wurm KW, et al. Among authors: bednarski pj. ChemMedChem. 2022 Aug 17;17(16):e202200262. doi: 10.1002/cmdc.202200262. Epub 2022 Jul 7. ChemMedChem. 2022. PMID: 35687532 Free PMC article.

10

Modifications of the Triaminoaryl Metabophore of Flupirtine and Retigabine Aimed at Avoiding Quinone Diimine Formation.

Wurm KW, Bartz FM, Schulig L, Bodtke A, Bednarski PJ, Link A. Wurm KW, et al. Among authors: bednarski pj. ACS Omega. 2022 Feb 25;7(9):7989-8012. doi: 10.1021/acsomega.1c07103. eCollection 2022 Mar 8. ACS Omega. 2022. PMID: 35284765 Free PMC article.

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