Hatcher JM - Search Results

1

Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors.

Malone CF, Kim M, Alexe G, Engel K, Forman AB, Robichaud A, Conway AS, Goodale A, Meyer A, Khalid D, Thayakumar A, Hatcher JM, Gray NS, Piccioni F, Stegmaier K. Malone CF, et al. Among authors: hatcher jm. Cancer Res. 2023 Jan 18;83(2):285-300. doi: 10.1158/0008-5472.CAN-21-4309. Cancer Res. 2023. PMID: 36398965 Free PMC article.

2

Brain Penetrant LRRK2 Inhibitor.

Choi HG, Zhang J, Deng X, Hatcher JM, Patricelli MP, Zhao Z, Alessi DR, Gray NS. Choi HG, et al. Among authors: hatcher jm. ACS Med Chem Lett. 2012 Aug 9;3(8):658-662. doi: 10.1021/ml300123a. Epub 2012 Jun 18. ACS Med Chem Lett. 2012. PMID: 23066449 Free PMC article.

3

Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor.

Hatcher JM, Zhang J, Choi HG, Ito G, Alessi DR, Gray NS. Hatcher JM, et al. ACS Med Chem Lett. 2015 Apr 7;6(5):584-9. doi: 10.1021/acsmedchemlett.5b00064. eCollection 2015 May 14. ACS Med Chem Lett. 2015. PMID: 26005538 Free PMC article.

4

Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer.

Terai H, Tan L, Beauchamp EM, Hatcher JM, Liu Q, Meyerson M, Gray NS, Hammerman PS. Terai H, et al. Among authors: hatcher jm. ACS Chem Biol. 2015 Dec 18;10(12):2687-96. doi: 10.1021/acschembio.5b00655. Epub 2015 Sep 25. ACS Chem Biol. 2015. PMID: 26390252 Free PMC article.

5

Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation.

Hatcher JM, Bahcall M, Choi HG, Gao Y, Sim T, George R, Jänne PA, Gray NS. Hatcher JM, et al. J Med Chem. 2015 Dec 10;58(23):9296-9308. doi: 10.1021/acs.jmedchem.5b01136. Epub 2015 Nov 25. J Med Chem. 2015. PMID: 26568289 Free PMC article.

6

Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor.

Hatcher JM, Weisberg E, Sim T, Stone RM, Liu S, Griffin JD, Gray NS. Hatcher JM, et al. ACS Med Chem Lett. 2016 Mar 8;7(5):476-81. doi: 10.1021/acsmedchemlett.5b00498. eCollection 2016 May 12. ACS Med Chem Lett. 2016. PMID: 27190596 Free PMC article.

7

Small-Molecule Inhibitors of LRRK2.

Hatcher JM, Choi HG, Alessi DR, Gray NS. Hatcher JM, et al. Adv Neurobiol. 2017;14:241-264. doi: 10.1007/978-3-319-49969-7_13. Adv Neurobiol. 2017. PMID: 28353288 Review.

8

Crystal structure of human IRAK1.

Wang L, Qiao Q, Ferrao R, Shen C, Hatcher JM, Buhrlage SJ, Gray NS, Wu H. Wang L, et al. Among authors: hatcher jm. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13507-13512. doi: 10.1073/pnas.1714386114. Epub 2017 Dec 5. Proc Natl Acad Sci U S A. 2017. PMID: 29208712 Free PMC article.

9

SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform.

Hatcher JM, Wu G, Zeng C, Zhu J, Meng F, Patel S, Wang W, Ficarro SB, Leggett AL, Powell CE, Marto JA, Zhang K, Ki Ngo JC, Fu XD, Zhang T, Gray NS. Hatcher JM, et al. Cell Chem Biol. 2018 Apr 19;25(4):460-470.e6. doi: 10.1016/j.chembiol.2018.01.013. Epub 2018 Feb 22. Cell Chem Biol. 2018. PMID: 29478907 Free PMC article.

10

Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8.

Hatcher JM, Wang ES, Johannessen L, Kwiatkowski N, Sim T, Gray NS. Hatcher JM, et al. ACS Med Chem Lett. 2018 Mar 18;9(6):540-545. doi: 10.1021/acsmedchemlett.8b00011. eCollection 2018 Jun 14. ACS Med Chem Lett. 2018. PMID: 29937979 Free PMC article.

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