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180 results

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Page 1
POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells.
Schrempf A, Bernardo S, Arasa Verge EA, Ramirez Otero MA, Wilson J, Kirchhofer D, Timelthaler G, Ambros AM, Kaya A, Wieder M, Ecker GF, Winter GE, Costanzo V, Loizou JI. Schrempf A, et al. Among authors: ecker gf. Cell Rep. 2022 Nov 29;41(9):111716. doi: 10.1016/j.celrep.2022.111716. Epub 2022 Nov 17. Cell Rep. 2022. PMID: 36400033 Free article.
Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors.
Dvorak V, Casiraghi A, Colas C, Koren A, Tomek T, Offensperger F, Rukavina A, Tin G, Hahn E, Dobner S, Frommelt F, Boeszoermenyi A, Bernada V, Hannich JT, Ecker GF, Winter GE, Kubicek S, Superti-Furga G. Dvorak V, et al. Among authors: ecker gf. Cell Chem Biol. 2023 Aug 17;30(8):953-964.e9. doi: 10.1016/j.chembiol.2023.06.029. Epub 2023 Jul 28. Cell Chem Biol. 2023. PMID: 37516113 Free PMC article.
Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8.
Ferrada E, Wiedmer T, Wang WA, Frommelt F, Steurer B, Klimek C, Lindinger S, Osthushenrich T, Garofoli A, Brocchetti S, Bradberry S, Huang J, MacNamara A, Scarabottolo L, Ecker GF, Malarstig A, Superti-Furga G. Ferrada E, et al. Among authors: ecker gf. J Mol Biol. 2024 Jan 15;436(2):168383. doi: 10.1016/j.jmb.2023.168383. Epub 2023 Dec 7. J Mol Biol. 2024. PMID: 38070861 Free article.
Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors.
van der Noord VE, van der Stel W, Louwerens G, Verhoeven D, Kuiken HJ, Lieftink C, Grandits M, Ecker GF, Beijersbergen RL, Bouwman P, Le Dévédec SE, van de Water B. van der Noord VE, et al. Among authors: ecker gf. Breast Cancer Res. 2023 May 5;25(1):51. doi: 10.1186/s13058-023-01648-x. Breast Cancer Res. 2023. PMID: 37147730 Free PMC article.
Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily.
Digles D, Ingles-Prieto A, Dvorak V, Mocking TAM, Goldmann U, Garofoli A, Homan EJ, Di Silvio A, Azzollini L, Sassone F, Fogazza M, Bärenz F, Pommereau A, Zuschlag Y, Ooms JF, Tranberg-Jensen J, Hansen JS, Stanka J, Sijben HJ, Batoulis H, Bender E, Martini R, IJzerman AP, Sauer DB, Heitman LH, Manolova V, Reinhardt J, Ehrmann A, Leippe P, Ecker GF, Huber KVM, Licher T, Scarabottolo L, Wiedmer T, Superti-Furga G. Digles D, et al. Among authors: ecker gf. Front Pharmacol. 2024 Jul 9;15:1401599. doi: 10.3389/fphar.2024.1401599. eCollection 2024. Front Pharmacol. 2024. PMID: 39050757 Free PMC article.
Development of new Kir2.1 channel openers from propafenone analogues.
Li E, Boujeddaine N, Houtman MJC, Maas RGC, Sluijter JPG, Ecker GF, Stary-Weinzinger A, van Ham WB, van der Heyden MAG. Li E, et al. Among authors: ecker gf. Br J Pharmacol. 2025 Feb;182(3):633-650. doi: 10.1111/bph.17377. Epub 2024 Oct 17. Br J Pharmacol. 2025. PMID: 39419581
180 results