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183 results

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Biofabrication of synthetic human liver tissue with advanced programmable functions.
Florentino RM, Morita K, Haep N, Motomura T, Diaz-Aragon R, Faccioli LAP, Collin de l'Hortet A, Cetin Z, Frau C, Vernetti L, Amler AK, Thomas A, Lam T, Kloke L, Takeishi K, Taylor DL, Fox IJ, Soto-Gutierrez A. Florentino RM, et al. Among authors: fox ij. iScience. 2022 Nov 4;25(12):105503. doi: 10.1016/j.isci.2022.105503. eCollection 2022 Dec 22. iScience. 2022. PMID: 36404924 Free PMC article.
Human Induced Pluripotent Stem Cell based Hepatic-Modeling of Lipid metabolism associated TM6SF2 E167K variant.
Faccioli LA, Sun Y, Motomura T, Liu Z, Kurihara T, Hu Z, Cetin Z, Franks J, Stolz D, Ostrowska A, Florentino RM, Fox IJ, Soto-Gutierrez A. Faccioli LA, et al. Among authors: fox ij. bioRxiv [Preprint]. 2023 Dec 18:2023.12.18.572248. doi: 10.1101/2023.12.18.572248. bioRxiv. 2023. Update in: Hepatology. 2024 Aug 27. doi: 10.1097/HEP.0000000000001065 PMID: 38187603 Free PMC article. Updated. Preprint.
Human-induced pluripotent stem cell-based hepatic modeling of lipid metabolism-associated TM6SF2-E167K variant.
Faccioli LAP, Sun Y, Animasahun O, Motomura T, Liu Z, Kurihara T, Hu Z, Yang B, Cetin Z, Baratta AM, Shankaran A, Nenwani M, Altay LN, Huang L, Meurs N, Franks J, Stolz D, Gavlock DC, Miedel MT, Ostrowska A, Florentino RM, Fox IJ, Nagrath D, Soto-Gutierrez A. Faccioli LAP, et al. Among authors: fox ij. Hepatology. 2024 Aug 27. doi: 10.1097/HEP.0000000000001065. Online ahead of print. Hepatology. 2024. PMID: 39190693
Variants in autophagy genes MTMR12 and FAM134A are putative modifiers of the hepatic phenotype in α1-antitrypsin deficiency.
Tafaleng EN, Li J, Wang Y, Hidvegi T, Soto-Gutierrez A, Locke AE, Nicholas TJ, Wang YC, Pak S, Cho MH, Silverman EK, Silverman GA, Jin SC, Fox IJ, Perlmutter DH. Tafaleng EN, et al. Among authors: fox ij. Hepatology. 2024 Oct 1;80(4):859-871. doi: 10.1097/HEP.0000000000000865. Epub 2024 Apr 1. Hepatology. 2024. PMID: 38557779 Free PMC article.
A non-human primate model of acute liver failure suitable for testing liver support systems.
Kalsi RS, Ostrowska A, Olson A, Quader M, Deutsch M, Arbujas-Silva NJ, Symmonds J, Soto-Gutierrez A, Crowley JJ, Reyes-Mugica M, Sanchez-Guerrero G, Jaeschke H, Amiot BP, Cascalho M, Nyberg SL, Platt JL, Tafaleng EN, Fox IJ. Kalsi RS, et al. Among authors: fox ij. Front Med (Lausanne). 2022 Sep 30;9:964448. doi: 10.3389/fmed.2022.964448. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36250086 Free PMC article.
Hepatocyte Nuclear Factor 4 alpha 2 Messenger RNA Reprograms Liver-Enriched Transcription Factors and Functional Proteins in End-Stage Cirrhotic Human Hepatocytes.
Tafaleng EN, Mukherjee A, Bell A, Morita K, Guzman-Lepe J, Haep N, Florentino RM, Diaz-Aragon R, Frau C, Ostrowska A, Schultz JR, Martini PGV, Soto-Gutierrez A, Fox IJ. Tafaleng EN, et al. Among authors: fox ij. Hepatol Commun. 2021 Nov;5(11):1911-1926. doi: 10.1002/hep4.1763. Epub 2021 Jul 1. Hepatol Commun. 2021. PMID: 34558820 Free PMC article.
Synthetic human livers for modeling metabolic diseases.
Tafaleng EN, Malizio MR, Fox IJ, Soto-Gutierrez A. Tafaleng EN, et al. Among authors: fox ij. Curr Opin Gastroenterol. 2021 May 1;37(3):224-230. doi: 10.1097/MOG.0000000000000726. Curr Opin Gastroenterol. 2021. PMID: 33769378 Free PMC article. Review.
Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells.
Takeishi K, Collin de l'Hortet A, Wang Y, Handa K, Guzman-Lepe J, Matsubara K, Morita K, Jang S, Haep N, Florentino RM, Yuan F, Fukumitsu K, Tobita K, Sun W, Franks J, Delgado ER, Shapiro EM, Fraunhoffer NA, Duncan AW, Yagi H, Mashimo T, Fox IJ, Soto-Gutierrez A. Takeishi K, et al. Among authors: fox ij. Cell Rep. 2020 Jun 2;31(9):107711. doi: 10.1016/j.celrep.2020.107711. Cell Rep. 2020. PMID: 32492423 Free PMC article.
183 results