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Selective Inhibition of Bruton's Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors.
Sousa BB, de Almeida CR, Barahona AF, Lopes R, Martins-Logrado A, Cavaco M, Neves V, Carvalho LAR, Labão-Almeida C, Coelho AR, Leal Bento M, Lopes RMRM, Oliveira BL, Castanho MARB, Neumeister P, Deutsch A, Vladimer GI, Krall N, João C, Corzana F, Seixas JD, Fior R, Bernardes GJL. Sousa BB, et al. Among authors: castanho marb. ACS Pharmacol Transl Sci. 2022 Nov 2;5(11):1156-1168. doi: 10.1021/acsptsci.2c00163. eCollection 2022 Nov 11. ACS Pharmacol Transl Sci. 2022. PMID: 36407952 Free PMC article.
The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer's Disease Pathophysiology.
Belo RF, Martins MLF, Shvachiy L, Costa-Coelho T, de Almeida-Borlido C, Fonseca-Gomes J, Neves V, Vicente Miranda H, Outeiro TF, Coelho JE, Xapelli S, Valente CA, Heras M, Bardaji E, Castanho MARB, Diógenes MJ, Sebastião AM. Belo RF, et al. Among authors: castanho marb. Front Pharmacol. 2020 Jul 9;11:985. doi: 10.3389/fphar.2020.00985. eCollection 2020. Front Pharmacol. 2020. PMID: 32733240 Free PMC article.
Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects.
Gallo M, Moreno E, Defaus S, Ortega-Alvaro A, Gonzalez A, Robledo P, Cavaco M, Neves V, Castanho MARB, Casadó V, Pardo L, Maldonado R, Andreu D. Gallo M, et al. Among authors: castanho marb. J Med Chem. 2021 May 27;64(10):6937-6948. doi: 10.1021/acs.jmedchem.1c00484. Epub 2021 Apr 22. J Med Chem. 2021. PMID: 33887904 Free PMC article.
193 results