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Page 1
Selective Inhibition of Bruton's Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors.
Sousa BB, de Almeida CR, Barahona AF, Lopes R, Martins-Logrado A, Cavaco M, Neves V, Carvalho LAR, Labão-Almeida C, Coelho AR, Leal Bento M, Lopes RMRM, Oliveira BL, Castanho MARB, Neumeister P, Deutsch A, Vladimer GI, Krall N, João C, Corzana F, Seixas JD, Fior R, Bernardes GJL. Sousa BB, et al. Among authors: corzana f. ACS Pharmacol Transl Sci. 2022 Nov 2;5(11):1156-1168. doi: 10.1021/acsptsci.2c00163. eCollection 2022 Nov 11. ACS Pharmacol Transl Sci. 2022. PMID: 36407952 Free PMC article.
A simple structural-based approach to prevent aminoglycoside inactivation by bacterial defense proteins. Conformational restriction provides effective protection against neomycin-B nucleotidylation by ANT4.
Asensio JL, Hidalgo A, Bastida A, Torrado M, Corzana F, Chiara JL, García-Junceda E, Cañada J, Jiménez-Barbero J. Asensio JL, et al. Among authors: corzana f. J Am Chem Soc. 2005 Jun 15;127(23):8278-9. doi: 10.1021/ja051722z. J Am Chem Soc. 2005. PMID: 15941249 Free article.
Molecular recognition of aminoglycoside antibiotics by bacterial defence proteins: NMR study of the structural and conformational features of streptomycin inactivation by Bacillus subtilis aminoglycoside-6-adenyl transferase.
Corzana F, Cuesta I, Bastida A, Hidalgo A, Latorre M, González C, García-Junceda E, Jiménez-Barbero J, Asensio JL. Corzana F, et al. Chemistry. 2005 Aug 19;11(17):5102-13. doi: 10.1002/chem.200400941. Chemistry. 2005. PMID: 15984036
A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2.
Valero-González J, Leonhard-Melief C, Lira-Navarrete E, Jiménez-Osés G, Hernández-Ruiz C, Pallarés MC, Yruela I, Vasudevan D, Lostao A, Corzana F, Takeuchi H, Haltiwanger RS, Hurtado-Guerrero R. Valero-González J, et al. Among authors: corzana f. Nat Chem Biol. 2016 Apr;12(4):240-6. doi: 10.1038/nchembio.2019. Epub 2016 Feb 8. Nat Chem Biol. 2016. PMID: 26854667 Free PMC article.
Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases.
Trastoy B, Du JJ, Cifuente JO, Rudolph L, García-Alija M, Klontz EH, Deredge D, Sultana N, Huynh CG, Flowers MW, Li C, Sastre DE, Wang LX, Corzana F, Mallagaray A, Sundberg EJ, Guerin ME. Trastoy B, et al. Among authors: corzana f. Nat Commun. 2023 Mar 27;14(1):1705. doi: 10.1038/s41467-023-37215-3. Nat Commun. 2023. PMID: 36973249 Free PMC article.
150 results