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Page 1
Selective Inhibition of Bruton's Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors.
Sousa BB, de Almeida CR, Barahona AF, Lopes R, Martins-Logrado A, Cavaco M, Neves V, Carvalho LAR, Labão-Almeida C, Coelho AR, Leal Bento M, Lopes RMRM, Oliveira BL, Castanho MARB, Neumeister P, Deutsch A, Vladimer GI, Krall N, João C, Corzana F, Seixas JD, Fior R, Bernardes GJL. Sousa BB, et al. Among authors: labao almeida c. ACS Pharmacol Transl Sci. 2022 Nov 2;5(11):1156-1168. doi: 10.1021/acsptsci.2c00163. eCollection 2022 Nov 11. ACS Pharmacol Transl Sci. 2022. PMID: 36407952 Free PMC article.
De novo design of potent and selective mimics of IL-2 and IL-15.
Silva DA, Yu S, Ulge UY, Spangler JB, Jude KM, Labão-Almeida C, Ali LR, Quijano-Rubio A, Ruterbusch M, Leung I, Biary T, Crowley SJ, Marcos E, Walkey CD, Weitzner BD, Pardo-Avila F, Castellanos J, Carter L, Stewart L, Riddell SR, Pepper M, Bernardes GJL, Dougan M, Garcia KC, Baker D. Silva DA, et al. Among authors: labao almeida c. Nature. 2019 Jan;565(7738):186-191. doi: 10.1038/s41586-018-0830-7. Epub 2019 Jan 9. Nature. 2019. PMID: 30626941 Free PMC article.
De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
Rebelo M, Tang C, Coelho AR, Labão-Almeida C, Schneider MM, Tatalick L, Ruivo P, de Miranda MP, Gomes A, Carvalho T, Walker MJ, Ausserwoeger H, Pedro Simas J, Veldhoen M, Knowles TPJ, Silva DA, Shoultz D, Bernardes GJL. Rebelo M, et al. Among authors: labao almeida c. J Infect Dis. 2023 Sep 15;228(6):723-733. doi: 10.1093/infdis/jiad135. J Infect Dis. 2023. PMID: 37279654 Free PMC article.
Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity.
van de Pavert SA, Ferreira M, Domingues RG, Ribeiro H, Molenaar R, Moreira-Santos L, Almeida FF, Ibiza S, Barbosa I, Goverse G, Labão-Almeida C, Godinho-Silva C, Konijn T, Schooneman D, O'Toole T, Mizee MR, Habani Y, Haak E, Santori FR, Littman DR, Schulte-Merker S, Dzierzak E, Simas JP, Mebius RE, Veiga-Fernandes H. van de Pavert SA, et al. Among authors: labao almeida c. Nature. 2014 Apr 3;508(7494):123-7. doi: 10.1038/nature13158. Epub 2014 Mar 19. Nature. 2014. PMID: 24670648 Free PMC article.