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Evaluation of Human Hepatocyte Drug Metabolism Carrying High-Risk or Protection-Associated Liver Disease Genetic Variants.
Faccioli LAP, Cetin Z, Kocas-Kilicarslan ZN, Ortiz K, Sun Y, Hu Z, Kurihara T, Tafaleng EN, Florentino RM, Wang Z, Xia M, Miedel MT, Taylor DL, Behari J, Ostrowska A, Constantine R, Li A, Soto-Gutierrez A. Faccioli LAP, et al. Int J Mol Sci. 2023 Aug 29;24(17):13406. doi: 10.3390/ijms241713406. Int J Mol Sci. 2023. PMID: 37686209 Free PMC article.
Human induced pluripotent stem cell based hepatic-modeling of lipid metabolism associated TM6SF2 E167K variant.
Faccioli LA, Sun Y, Animasahun O, Motomura T, Liu Z, Kurihara T, Hu Z, Yang B, Cetin Z, Baratta AM, Shankaran A, Nenwani M, Altay LN, Huang L, Meurs N, Franks J, Stolz D, Gavlock DC, Miedel MT, Ostrowska A, Florentino RM, Fox IJ, Nagrath D, Soto-Gutierrez A. Faccioli LA, et al. Among authors: soto gutierrez a. Hepatology. 2024 Aug 27. doi: 10.1097/HEP.0000000000001065. Online ahead of print. Hepatology. 2024. PMID: 39190693
Human Induced Pluripotent Stem Cell based Hepatic-Modeling of Lipid metabolism associated TM6SF2 E167K variant.
Faccioli LA, Sun Y, Motomura T, Liu Z, Kurihara T, Hu Z, Cetin Z, Franks J, Stolz D, Ostrowska A, Florentino RM, Fox IJ, Soto-Gutierrez A. Faccioli LA, et al. Among authors: soto gutierrez a. bioRxiv [Preprint]. 2023 Dec 18:2023.12.18.572248. doi: 10.1101/2023.12.18.572248. bioRxiv. 2023. Update in: Hepatology. 2024 Aug 27. doi: 10.1097/HEP.0000000000001065 PMID: 38187603 Free PMC article. Updated. Preprint.
Human Hepatocellular response in Cholestatic Liver Diseases.
Ortiz K, Cetin Z, Sun Y, Hu Z, Kurihara T, Tafaleng EN, Florentino RM, Ostrowska A, Soto-Gutierrez A, Faccioli LAP. Ortiz K, et al. Organogenesis. 2023 Dec 31;19(1):2247576. doi: 10.1080/15476278.2023.2247576. Organogenesis. 2023. PMID: 37598346 Free PMC article.
VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis.
Rizvi F, Lee YR, Diaz-Aragon R, Bawa PS, So J, Florentino RM, Wu S, Sarjoo A, Truong E, Smith AR, Wang F, Everton E, Ostrowska A, Jung K, Tam Y, Muramatsu H, Pardi N, Weissman D, Soto-Gutierrez A, Shin D, Gouon-Evans V. Rizvi F, et al. Cell Stem Cell. 2023 Dec 7;30(12):1640-1657.e8. doi: 10.1016/j.stem.2023.10.008. Epub 2023 Nov 28. Cell Stem Cell. 2023. PMID: 38029740 Free PMC article.
A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system.
Aleman J, K R, Wiegand C, Schurdak ME, Vernetti L, Gavlock D, Reese C, DeBiasio R, LaRocca G, Angarita YD, Gough A, Soto-Gutierrez A, Behari J, Yechoor VK, Miedel MT, Stern AM, Banerjee I, Taylor DL. Aleman J, et al. Among authors: soto gutierrez a. Commun Biol. 2024 Oct 14;7(1):1317. doi: 10.1038/s42003-024-07006-7. Commun Biol. 2024. PMID: 39397070 Free PMC article.
Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy.
Xia M, Varmazyad M, Pla-Palacín I, Gavlock DC, DeBiasio R, LaRocca G, Reese C, Florentino RM, Faccioli LAP, Brown JA, Vernetti LA, Schurdak M, Stern AM, Gough A, Behari J, Soto-Gutierrez A, Taylor DL, Miedel MT. Xia M, et al. Among authors: soto gutierrez a. Front Cell Dev Biol. 2024 Sep 11;12:1423936. doi: 10.3389/fcell.2024.1423936. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 39324073 Free PMC article.
Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy.
Xia M, Varmazyad M, Palacin IP, Gavlock DC, Debiasio R, LaRocca G, Reese C, Florentino R, Faccioli LAP, Brown JA, Vernetti LA, Schurdak ME, Stern AM, Gough A, Behari J, Soto-Gutierrez A, Taylor DL, Miedel M. Xia M, et al. Among authors: soto gutierrez a. bioRxiv [Preprint]. 2024 May 7:2024.04.22.590608. doi: 10.1101/2024.04.22.590608. bioRxiv. 2024. Update in: Front Cell Dev Biol. 2024 Sep 11;12:1423936. doi: 10.3389/fcell.2024.1423936 PMID: 38712213 Free PMC article. Updated. Preprint.
117 results