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Gaps in our understanding of how vagal afferents to the small intestinal mucosa detect luminal stimuli.

Fox EA, Serlin HK. Fox EA, et al. Among authors: serlin hk. Am J Physiol Regul Integr Comp Physiol. 2024 Aug 1;327(2):R173-R187. doi: 10.1152/ajpregu.00252.2023. Epub 2024 Jun 11. Am J Physiol Regul Integr Comp Physiol. 2024. PMID: 38860288 Review.

Intestinal enteroendocrine cells rely on ryanodine and IP₃ calcium store receptors for mechanotransduction.

Knutson KR, Whiteman ST, Alcaino C, Mercado-Perez A, Finholm I, Serlin HK, Bellampalli SS, Linden DR, Farrugia G, Beyder A. Knutson KR, et al. Among authors: serlin hk. J Physiol. 2023 Jan;601(2):287-305. doi: 10.1113/JP283383. Epub 2022 Dec 13. J Physiol. 2023. PMID: 36428286 Free PMC article.

Neurotrophin-4 is essential for survival of the majority of vagal afferents to the mucosa of the small intestine, but not the stomach.

Serlin HK, Fox EA. Serlin HK, et al. Auton Neurosci. 2021 Jul;233:102811. doi: 10.1016/j.autneu.2021.102811. Epub 2021 Apr 19. Auton Neurosci. 2021. PMID: 33932866

Abdominal vagotomy reveals majority of small intestinal mucosal afferents labeled in na_v 1.8cre-rosa26tdTomato mice are vagal in origin.

Serlin HK, Fox EA. Serlin HK, et al. J Comp Neurol. 2020 Apr 1;528(5):816-839. doi: 10.1002/cne.24791. Epub 2019 Nov 5. J Comp Neurol. 2020. PMID: 31618460

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