Pointon A - Search Results

1

Prediction of inotropic effect based on calcium transients in human iPSC-derived cardiomyocytes and machine learning.

Yang H, Obrezanova O, Pointon A, Stebbeds W, Francis J, Beattie KA, Clements P, Harvey JS, Smith GF, Bender A. Yang H, et al. Among authors: pointon a. Toxicol Appl Pharmacol. 2023 Jan 15;459:116342. doi: 10.1016/j.taap.2022.116342. Epub 2022 Dec 9. Toxicol Appl Pharmacol. 2023. PMID: 36502871 Free article.

2

Information-Derived Mechanistic Hypotheses for Structural Cardiotoxicity.

Svensson F, Zoufir A, Mahmoud S, Afzal AM, Smit I, Giblin KA, Clements PJ, Mettetal JT, Pointon A, Harvey JS, Greene N, Williams RV, Bender A. Svensson F, et al. Among authors: pointon a. Chem Res Toxicol. 2018 Nov 19;31(11):1119-1127. doi: 10.1021/acs.chemrestox.8b00159. Epub 2018 Oct 17. Chem Res Toxicol. 2018. PMID: 30350600

3

Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning.

Yang H, Stebbeds W, Francis J, Pointon A, Obrezanova O, Beattie KA, Clements P, Harvey JS, Smith GF, Bender A. Yang H, et al. Among authors: pointon a. Stem Cell Reports. 2022 Mar 8;17(3):556-568. doi: 10.1016/j.stemcr.2022.01.009. Epub 2022 Feb 10. Stem Cell Reports. 2022. PMID: 35148844 Free PMC article.

4

In silico approaches in organ toxicity hazard assessment: Current status and future needs for predicting heart, kidney and lung toxicities.

Bassan A, Alves VM, Amberg A, Anger LT, Beilke L, Bender A, Bernal A, Cronin MTD, Hsieh JH, Johnson C, Kemper R, Mumtaz M, Neilson L, Pavan M, Pointon A, Pletz J, Ruiz P, Russo DP, Sabnis Y, Sandhu R, Schaefer M, Stavitskaya L, Szabo DT, Valentin JP, Woolley D, Zwickl C, Myatt GJ. Bassan A, et al. Among authors: pointon a. Comput Toxicol. 2021 Nov;20:100188. doi: 10.1016/j.comtox.2021.100188. Epub 2021 Sep 13. Comput Toxicol. 2021. PMID: 35721273 Free PMC article.

5

Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes.

Raniga K, Nasir A, Vo NTN, Vaidyanathan R, Dickerson S, Hilcove S, Mosqueira D, Mirams GR, Clements P, Hicks R, Pointon A, Stebbeds W, Francis J, Denning C. Raniga K, et al. Among authors: pointon a. Cell Stem Cell. 2024 Mar 7;31(3):292-311. doi: 10.1016/j.stem.2024.01.007. Epub 2024 Feb 15. Cell Stem Cell. 2024. PMID: 38366587 Free article. Review.

6

Computational approaches identify a transcriptomic fingerprint of drug-induced structural cardiotoxicity.

Au Yeung VPW, Obrezanova O, Zhou J, Yang H, Bowen TJ, Ivanov D, Saffadi I, Carter AS, Subramanian V, Dillmann I, Hall A, Corrigan A, Viant MR, Pointon A. Au Yeung VPW, et al. Among authors: pointon a. Cell Biol Toxicol. 2024 Jun 28;40(1):50. doi: 10.1007/s10565-024-09880-7. Cell Biol Toxicol. 2024. PMID: 38940987 Free PMC article.

7

Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment.

Morris CJ, Rolf MG, Starnes L, Villar IC, Pointon A, Kimko H, Di Veroli GY. Morris CJ, et al. Among authors: pointon a. Front Pharmacol. 2024 Oct 29;15:1402462. doi: 10.3389/fphar.2024.1402462. eCollection 2024. Front Pharmacol. 2024. PMID: 39534082 Free PMC article.

8

Assessment of cardiomyocyte contraction in human-induced pluripotent stem cell-derived cardiomyocytes.

Pointon A, Harmer AR, Dale IL, Abi-Gerges N, Bowes J, Pollard C, Garside H. Pointon A, et al. Toxicol Sci. 2015 Apr;144(2):227-37. doi: 10.1093/toxsci/kfu312. Epub 2014 Dec 22. Toxicol Sci. 2015. PMID: 25538221

9

Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues.

Ravenscroft SM, Pointon A, Williams AW, Cross MJ, Sidaway JE. Ravenscroft SM, et al. Among authors: pointon a. Toxicol Sci. 2016 Jul;152(1):99-112. doi: 10.1093/toxsci/kfw069. Epub 2016 Apr 28. Toxicol Sci. 2016. PMID: 27125969 Free PMC article.

10

RYR2 deficient human model identifies calcium handling and metabolic dysfunction impacting pharmacological responses.

Starnes L, Hall A, Etal D, Cavallo AL, Grabowski P, Gallon J, Kha M, Hicks R, Pointon A. Starnes L, et al. Among authors: pointon a. Front Cardiovasc Med. 2024 Jul 8;11:1357315. doi: 10.3389/fcvm.2024.1357315. eCollection 2024. Front Cardiovasc Med. 2024. PMID: 39041002 Free PMC article.

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