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The design of experiments (DoE) in optimization of an aerobic flow Pd-catalyzed oxidation of alcohol towards an important aldehyde precursor in the synthesis of phosphatidylinositide 3-kinase inhibitor (CPL302415).
Michałek S, Gurba-Bryśkiewicz L, Maruszak W, Zagozda M, Maj AM, Ochal Z, Dubiel K, Wieczorek M. Michałek S, et al. Among authors: wieczorek m. RSC Adv. 2022 Nov 23;12(52):33605-33611. doi: 10.1039/d2ra07003k. eCollection 2022 Nov 22. RSC Adv. 2022. PMID: 36505705 Free PMC article.
Preclinical characterization of CPL304110 as a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3 for gastric, bladder, and squamous cell lung cancer.
Popiel D, Stańczak A, Skupińska M, Mikołajczyk A, Stańczak P, Mituła F, Hucz-Kalitowska J, Jastrzębska K, Smuga D, Dominowski J, Delis M, Mulewski K, Pietruś W, Zdżalik-Bielecka D, Dzwonek K, Lamparska-Przybysz M, Yamani A, Olejkowska P, Piórkowska N, Dubiel K, Wieczorek M, Pieczykolan J. Popiel D, et al. Among authors: wieczorek m. Front Oncol. 2024 Jan 12;13:1293728. doi: 10.3389/fonc.2023.1293728. eCollection 2023. Front Oncol. 2024. PMID: 38282676 Free PMC article.
Development of the telescoped flow Pd-catalyzed aerobic alcohol oxidation/reductive amination sequence in the synthesis of new phosphatidylinositide 3-kinase inhibitor (CPL302415).
Michałek S, Maj AM, Gurba-Bryśkiewicz L, Maruszak W, Wiśniewski K, Zagozda M, Stypik M, Dubiel K, Wieczorek M. Michałek S, et al. Among authors: wieczorek m. RSC Adv. 2024 Sep 6;14(39):28516-28523. doi: 10.1039/d4ra04923c. eCollection 2024 Sep 4. RSC Adv. 2024. PMID: 39247513 Free PMC article.
First-in-human study of CPL207280, a novel G-protein-coupled receptor 40/free fatty acid receptor 1 agonist, in healthy volunteers after single and multiple administration.
Bazydło-Guzenda K, Jarus-Dziedzic K, Gierczak-Pachulska A, Buda P, Rudzki PJ, Buś-Kwaśnik K, Juszczyk E, Tratkiewicz E, Rabczenko D, Segiet-Święcicka A, Wieczorek M. Bazydło-Guzenda K, et al. Among authors: wieczorek m. Diabetes Obes Metab. 2024 Apr;26(4):1376-1385. doi: 10.1111/dom.15439. Epub 2024 Jan 11. Diabetes Obes Metab. 2024. PMID: 38204407
574 results