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Mode of action of p-quinone derivatives with trypanocidal activity studied by experimental and in silico models.
Ballesteros-Casallas A, Quiroga C, Ortiz C, Benítez D, Denis PA, Figueroa D, Salas CO, Bertrand J, Tapia RA, Sánchez P, Miscione GP, Comini MA, Paulino M. Ballesteros-Casallas A, et al. Among authors: bertrand j. Eur J Med Chem. 2023 Jan 15;246:114926. doi: 10.1016/j.ejmech.2022.114926. Epub 2022 Nov 17. Eur J Med Chem. 2023. PMID: 36508970
Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia.
Bertrand J, Dostálová H, Kryštof V, Jorda R, Delgado T, Castro-Alvarez A, Mella J, Cabezas D, Faúndez M, Espinosa-Bustos C, Salas CO. Bertrand J, et al. Pharmaceutics. 2022 Jun 17;14(6):1294. doi: 10.3390/pharmaceutics14061294. Pharmaceutics. 2022. PMID: 35745866 Free PMC article.
New Inhibitors of Bcr-Abl Based on 2,6,9-Trisubstituted Purine Scaffold Elicit Cytotoxicity in Chronic Myeloid Leukemia-Derived Cell Lines Sensitive and Resistant to TKIs.
Delgado T, Veselá D, Dostálová H, Kryštof V, Vojáčková V, Jorda R, Castro A, Bertrand J, Rivera G, Faúndez M, Strnad M, Espinosa-Bustos C, Salas CO. Delgado T, et al. Among authors: bertrand j. Pharmaceutics. 2024 May 11;16(5):649. doi: 10.3390/pharmaceutics16050649. Pharmaceutics. 2024. PMID: 38794311 Free PMC article.
New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer.
Espinosa-Bustos C, Bertrand J, Villegas-Menares A, Guerrero S, Di Marcotullio L, Navacci S, Schulte G, Kozielewicz P, Bloch N, Villela V, Paulino M, Kogan MJ, Cantero J, Salas CO. Espinosa-Bustos C, et al. Among authors: bertrand j. Bioorg Chem. 2024 Oct;151:107681. doi: 10.1016/j.bioorg.2024.107681. Epub 2024 Jul 28. Bioorg Chem. 2024. PMID: 39106711
Human Oncostatin M deficiency underlies an inherited severe bone marrow failure syndrome.
Garrigue A, Kermasson L, Susini S, Fert I, Mahony CB, Sadek H, Luce S, Chouteau M, Cavazzana M, Six E, Le Bousse-Kerdilès MC, Anginot A, Souraud JB, Cormier-Daire V, Willems M, Sirvent A, Russello J, Callebaut I, André I, Bertrand JY, Lagresle-Peyrou C, Revy P. Garrigue A, et al. Among authors: bertrand jy. J Clin Invest. 2025 Jan 23:e180981. doi: 10.1172/JCI180981. Online ahead of print. J Clin Invest. 2025. PMID: 39847438
TRPC1 links calcium signaling to cellular senescence in the protection against post-traumatic osteoarthritis.
Sambale M, Lively S, Espin-Garcia O, Potla P, Pastrello C, Bödecker S, Wessendorf L, Kleimann S, Paruzel P, Asgarian R, Tosun A, Intemann J, Bertrand J, Dell'Accio F, Kapoor M, Pap T, Sherwood J. Sambale M, et al. Among authors: bertrand j. JCI Insight. 2024 Dec 24:e182103. doi: 10.1172/jci.insight.182103. Online ahead of print. JCI Insight. 2024. PMID: 39718827 Free article.
1,760 results