Clark R - Search Results

1

Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.

Goldberg FW, Kettle JG, Lamont GM, Buttar D, Ting AKT, McGuire TM, Cook CR, Beattie D, Morentin Gutierrez P, Kavanagh SL, Komen JC, Kawatkar A, Clark R, Hopcroft L, Hughes G, Critchlow SE. Goldberg FW, et al. Among authors: clark r. J Med Chem. 2023 Jan 12;66(1):384-397. doi: 10.1021/acs.jmedchem.2c01342. Epub 2022 Dec 16. J Med Chem. 2023. PMID: 36525250

2

Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines as α7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders.

Clark RB, Lamppu D, Libertine L, McDonough A, Kumar A, LaRosa G, Rush R, Elbaum D. Clark RB, et al. J Med Chem. 2014 May 22;57(10):3966-83. doi: 10.1021/jm5004599. Epub 2014 May 9. J Med Chem. 2014. PMID: 24814197

3

Design, Synthesis, and Biological Evaluation of Hexacyclic Tetracyclines as Potent, Broad Spectrum Antibacterial Agents.

Sun C, Hunt DK, Chen CL, Deng Y, He M, Clark RB, Fyfe C, Grossman TH, Sutcliffe JA, Xiao XY. Sun C, et al. J Med Chem. 2015 Jun 11;58(11):4703-12. doi: 10.1021/acs.jmedchem.5b00262. Epub 2015 May 20. J Med Chem. 2015. PMID: 25927406

4

Synthesis and biological evaluation of 8-aminomethyltetracycline derivatives as novel antibacterial agents.

Clark RB, He M, Deng Y, Sun C, Chen CL, Hunt DK, O'Brien WJ, Fyfe C, Grossman TH, Sutcliffe JA, Achorn C, Hogan PC, Katz CE, Niu J, Zhang WY, Zhu Z, Ronn M, Xiao XY. Clark RB, et al. J Med Chem. 2013 Oct 24;56(20):8112-38. doi: 10.1021/jm401211t. Epub 2013 Oct 3. J Med Chem. 2013. PMID: 24047201

5

Fluorocyclines. 1. 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: a potent, broad spectrum antibacterial agent.

Xiao XY, Hunt DK, Zhou J, Clark RB, Dunwoody N, Fyfe C, Grossman TH, O'Brien WJ, Plamondon L, Rönn M, Sun C, Zhang WY, Sutcliffe JA. Xiao XY, et al. J Med Chem. 2012 Jan 26;55(2):597-605. doi: 10.1021/jm201465w. Epub 2012 Jan 4. J Med Chem. 2012. PMID: 22148514

6

Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy.

Clark RB, Hunt DK, He M, Achorn C, Chen CL, Deng Y, Fyfe C, Grossman TH, Hogan PC, O'Brien WJ, Plamondon L, Rönn M, Sutcliffe JA, Zhu Z, Xiao XY. Clark RB, et al. J Med Chem. 2012 Jan 26;55(2):606-22. doi: 10.1021/jm201467r. Epub 2012 Jan 6. J Med Chem. 2012. PMID: 22148555

7

8-Azatetracyclines: synthesis and evaluation of a novel class of tetracycline antibacterial agents.

Clark RB, He M, Fyfe C, Lofland D, O'Brien WJ, Plamondon L, Sutcliffe JA, Xiao XY. Clark RB, et al. J Med Chem. 2011 Mar 10;54(5):1511-28. doi: 10.1021/jm1015389. Epub 2011 Feb 8. J Med Chem. 2011. PMID: 21302930 Free PMC article.

8

Indanylacetic acid derivatives carrying aryl-pyridyl and aryl-pyrimidinyl tail groups--new classes of PPAR gamma/delta and PPAR alpha/gamma/delta agonists.

Cantin LD, Liang S, Ogutu H, Iwuagwu CI, Boakye K, Bullock WH, Burns M, Clark R, Claus T, delaCruz FE, Daly M, Ehrgott FJ, Johnson JS, Keiper C, Livingston JN, Schoenleber RW, Shapiro J, Town C, Yang L, Tsutsumi M, Ma X. Cantin LD, et al. Among authors: clark r. Bioorg Med Chem Lett. 2007 Feb 15;17(4):1056-61. doi: 10.1016/j.bmcl.2006.11.025. Epub 2006 Nov 15. Bioorg Med Chem Lett. 2007. PMID: 17157013

9

Synthesis and antibacterial activity of pentacyclines: a novel class of tetracycline analogs.

Sun C, Hunt DK, Clark RB, Lofland D, O'Brien WJ, Plamondon L, Xiao XY. Sun C, et al. J Med Chem. 2011 Jun 9;54(11):3704-31. doi: 10.1021/jm1015395. Epub 2011 May 10. J Med Chem. 2011. PMID: 21500832 Free PMC article.

10

Discovery of Macrolide Antibiotics Effective against Multi-Drug Resistant Gram-Negative Pathogens.

Myers AG, Clark RB. Myers AG, et al. Acc Chem Res. 2021 Apr 6;54(7):1635-1645. doi: 10.1021/acs.accounts.1c00020. Epub 2021 Mar 10. Acc Chem Res. 2021. PMID: 33691070 Free article. Review.

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