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Page 1
Blood-based multivariate methylation risk score for cognitive impairment and dementia.
Koetsier J, Cavill R, Reijnders R, Harvey J, Homann J, Kouhsar M, Deckers K, Köhler S, Eijssen LMT, van den Hove DLA, Demuth I, Düzel S; Alzheimer's Disease Neuroimaging Initiative; Smith RG, Smith AR, Burrage J, Walker EM, Shireby G, Hannon E, Dempster E, Frayling T, Mill J, Dobricic V, Johannsen P, Wittig M, Franke A, Vandenberghe R, Schaeverbeke J, Freund-Levi Y, Frölich L, Scheltens P, Teunissen CE, Frisoni G, Blin O, Richardson JC, Bordet R, Engelborghs S, de Roeck E, Martinez-Lage P, Tainta M, Lleó A, Sala I, Popp J, Peyratout G, Verhey F, Tsolaki M, Andreasson U, Blennow K, Zetterberg H, Streffer J, Vos SJB, Lovestone S, Visser PJ, Lill CM, Bertram L, Lunnon K, Pishva E. Koetsier J, et al. Among authors: shireby g. Alzheimers Dement. 2024 Oct;20(10):6682-6698. doi: 10.1002/alz.14061. Epub 2024 Aug 28. Alzheimers Dement. 2024. PMID: 39193899 Free PMC article.
Genetic architecture of epigenetic cortical clock age in brain tissue from older individuals: alterations in CD46 and other loci.
Grodstein F, Lemos B, Yang J, de Paiva Lopes K, Vialle RA, Seyfried N, Wang Y, Shireby G, Hannon E, Thomas A, Brookes K, Mill J, De Jager PL, Bennett DA. Grodstein F, et al. Among authors: shireby g. Epigenetics. 2024 Dec;19(1):2392050. doi: 10.1080/15592294.2024.2392050. Epub 2024 Aug 22. Epigenetics. 2024. PMID: 39169872 Free PMC article.
Uncertainty quantification of reference-based cellular deconvolution algorithms.
Vellame DS, Shireby G, MacCalman A, Dempster EL, Burrage J, Gorrie-Stone T, Schalkwyk LS, Mill J, Hannon E. Vellame DS, et al. Among authors: shireby g. Epigenetics. 2023 Dec;18(1):2137659. doi: 10.1080/15592294.2022.2137659. Epub 2022 Dec 20. Epigenetics. 2023. PMID: 36539387 Free PMC article.
Machine learning-based prediction of cognitive outcomes in de novo Parkinson's disease.
Harvey J, Reijnders RA, Cavill R, Duits A, Köhler S, Eijssen L, Rutten BPF, Shireby G, Torkamani A, Creese B, Leentjens AFG, Lunnon K, Pishva E. Harvey J, et al. Among authors: shireby g. NPJ Parkinsons Dis. 2022 Nov 7;8(1):150. doi: 10.1038/s41531-022-00409-5. NPJ Parkinsons Dis. 2022. PMID: 36344548 Free PMC article.
DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types.
Shireby G, Dempster EL, Policicchio S, Smith RG, Pishva E, Chioza B, Davies JP, Burrage J, Lunnon K, Seiler Vellame D, Love S, Thomas A, Brookes K, Morgan K, Francis P, Hannon E, Mill J. Shireby G, et al. Nat Commun. 2022 Sep 24;13(1):5620. doi: 10.1038/s41467-022-33394-7. Nat Commun. 2022. PMID: 36153390 Free PMC article.
A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens.
Stevenson AJ, McCartney DL, Gadd DA, Shireby G, Hillary RF, King D, Tzioras M, Wrobel N, McCafferty S, Murphy L, McColl BW, Redmond P, Taylor AM, Harris SE, Russ TC, McIntosh AM, Mill J, Smith C, Deary IJ, Cox SR, Marioni RE, Spires-Jones TL. Stevenson AJ, et al. Among authors: shireby g. Eur J Neurosci. 2022 Nov;56(9):5637-5649. doi: 10.1111/ejn.15661. Epub 2022 Apr 6. Eur J Neurosci. 2022. PMID: 35362642 Free PMC article.
19 results