Hao J - Search Results

1

Human and nonclinical disposition of [¹⁴C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection.

Subramanian R, Ling J, Wang J, Wang K, Hao J, Jin H, Lai Y, Murray B, Wijaya S, Zhang H, Smith BJ. Subramanian R, et al. Among authors: hao j. Xenobiotica. 2022 Sep-Nov;52(9-11):973-985. doi: 10.1080/00498254.2022.2159569. Epub 2023 Jan 6. Xenobiotica. 2022. PMID: 36546430

2

Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat.

Lepist EI, Zhang X, Hao J, Huang J, Kosaka A, Birkus G, Murray BP, Bannister R, Cihlar T, Huang Y, Ray AS. Lepist EI, et al. Among authors: hao j. Kidney Int. 2014 Aug;86(2):350-7. doi: 10.1038/ki.2014.66. Epub 2014 Mar 19. Kidney Int. 2014. PMID: 24646860 Free PMC article.

3

In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation.

Liang X, Park Y, DeForest N, Hao J, Zhao X, Niu C, Wang K, Smith B, Lai Y. Liang X, et al. Among authors: hao j. Drug Metab Dispos. 2020 Dec;48(12):1283-1292. doi: 10.1124/dmd.120.000163. Epub 2020 Oct 9. Drug Metab Dispos. 2020. PMID: 33037043

4

Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys.

Cheng Y, Liang X, Hao J, Niu C, Lai Y. Cheng Y, et al. Among authors: hao j. Clin Transl Sci. 2021 Sep;14(5):1924-1934. doi: 10.1111/cts.13047. Epub 2021 May 31. Clin Transl Sci. 2021. PMID: 34058067 Free PMC article.

5

Human pharmacokinetics prediction with an in vitro-in vivo correction factor approach and in vitro drug-drug interaction profile of bictegravir, a potent integrase-strand transfer inhibitor component in approved biktarvy^® for the treatment of HIV-1 infection.

Subramanian R, Wang J, Murray B, Custodio J, Hao J, Lazerwith S, MacLennan Staiger K, Mwangi J, Sun H, Tang J, Wang K, Rhodes G, Wijaya S, Zhang H, Smith BJ. Subramanian R, et al. Among authors: hao j. Xenobiotica. 2022 Dec;52(12):1020-1030. doi: 10.1080/00498254.2023.2169207. Epub 2023 Jan 26. Xenobiotica. 2022. PMID: 36701274

6

Characterization of Elimination Pathways and the Feasibility of Endogenous Metabolites as Biomarkers of Organic Anion Transporter 1/3 Inhibition in Cynomolgus Monkeys.

Liu R, Hao J, Zhao X, Lai Y. Liu R, et al. Among authors: hao j. Drug Metab Dispos. 2023 Jul;51(7):844-850. doi: 10.1124/dmd.123.001277. Epub 2023 Apr 14. Drug Metab Dispos. 2023. PMID: 37059471

7

Lenacapavir Exhibits Atropisomerism-Mechanistic Pharmacokinetics and Disposition Studies of Lenacapavir Reveal Intestinal Excretion as a Major Clearance Pathway.

Zheng J, Lu B, Carr G, Mwangi J, Wang K, Hao J, Staiger KM, Kozon N, Murray BP, Bashir M, Gohdes MA, Tse WC, Schroeder S, Graupe M, Link JO, Yoon J, Chiu A, Rowe W, Smith BJ, Subramanian R. Zheng J, et al. Among authors: hao j. J Pharmacol Exp Ther. 2024 Sep 18;391(1):91-103. doi: 10.1124/jpet.124.002302. J Pharmacol Exp Ther. 2024. PMID: 39117460

8

Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy.

Murakami E, Wang T, Park Y, Hao J, Lepist EI, Babusis D, Ray AS. Murakami E, et al. Among authors: hao j. Antimicrob Agents Chemother. 2015;59(6):3563-9. doi: 10.1128/AAC.00128-15. Epub 2015 Apr 13. Antimicrob Agents Chemother. 2015. PMID: 25870059 Free PMC article.

9

Evaluation of the effect of cobicistat on the in vitro renal transport and cytotoxicity potential of tenofovir.

Stray KM, Bam RA, Birkus G, Hao J, Lepist EI, Yant SR, Ray AS, Cihlar T. Stray KM, et al. Among authors: hao j. Antimicrob Agents Chemother. 2013 Oct;57(10):4982-9. doi: 10.1128/AAC.00712-13. Epub 2013 Jul 29. Antimicrob Agents Chemother. 2013. PMID: 23896476 Free PMC article.

10

Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).

Liang X, Chien HC, Yee SW, Giacomini MM, Chen EC, Piao M, Hao J, Twelves J, Lepist EI, Ray AS, Giacomini KM. Liang X, et al. Among authors: hao j. Mol Pharm. 2015 Dec 7;12(12):4301-10. doi: 10.1021/acs.molpharmaceut.5b00501. Epub 2015 Nov 16. Mol Pharm. 2015. PMID: 26528626 Free PMC article.

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