Lai Y - Search Results

1

Human and nonclinical disposition of [¹⁴C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection.

Subramanian R, Ling J, Wang J, Wang K, Hao J, Jin H, Lai Y, Murray B, Wijaya S, Zhang H, Smith BJ. Subramanian R, et al. Among authors: lai y. Xenobiotica. 2022 Sep-Nov;52(9-11):973-985. doi: 10.1080/00498254.2022.2159569. Epub 2023 Jan 6. Xenobiotica. 2022. PMID: 36546430

2

Organic Anion-Transporting Polypeptide Genes Are Not Induced by the Pregnane X Receptor Activator Rifampin: Studies in Hepatocytes In Vitro and in Monkeys In Vivo.

Niu C, Wang Y, Zhao X, Tep S, Murakami E, Subramanian R, Smith B, Lai Y. Niu C, et al. Among authors: lai y. Drug Metab Dispos. 2019 Dec;47(12):1433-1442. doi: 10.1124/dmd.119.088922. Epub 2019 Oct 3. Drug Metab Dispos. 2019. PMID: 31582395

3

In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation.

Liang X, Park Y, DeForest N, Hao J, Zhao X, Niu C, Wang K, Smith B, Lai Y. Liang X, et al. Among authors: lai y. Drug Metab Dispos. 2020 Dec;48(12):1283-1292. doi: 10.1124/dmd.120.000163. Epub 2020 Oct 9. Drug Metab Dispos. 2020. PMID: 33037043

4

Transporter Gene Regulation in Sandwich Cultured Human Hepatocytes Through the Activation of Constitutive Androstane Receptor (CAR) or Aryl Hydrocarbon Receptor (AhR).

Niu C, Smith B, Lai Y. Niu C, et al. Among authors: lai y. Front Pharmacol. 2021 Jan 21;11:620197. doi: 10.3389/fphar.2020.620197. eCollection 2020. Front Pharmacol. 2021. PMID: 33551819 Free PMC article.

5

Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys.

Cheng Y, Liang X, Hao J, Niu C, Lai Y. Cheng Y, et al. Among authors: lai y. Clin Transl Sci. 2021 Sep;14(5):1924-1934. doi: 10.1111/cts.13047. Epub 2021 May 31. Clin Transl Sci. 2021. PMID: 34058067 Free PMC article.

6

Characterization of Elimination Pathways and the Feasibility of Endogenous Metabolites as Biomarkers of Organic Anion Transporter 1/3 Inhibition in Cynomolgus Monkeys.

Liu R, Hao J, Zhao X, Lai Y. Liu R, et al. Among authors: lai y. Drug Metab Dispos. 2023 Jul;51(7):844-850. doi: 10.1124/dmd.123.001277. Epub 2023 Apr 14. Drug Metab Dispos. 2023. PMID: 37059471

7

Assessing Pleiotropic Effects of a Mixed-Mode Perpetrator Drug, Rifampicin, by Multiple Endogenous Biomarkers in Dogs.

Liu R, Ma B, Mok MM, Murray BP, Subramanian R, Lai Y. Liu R, et al. Among authors: lai y. Drug Metab Dispos. 2024 Feb 14;52(3):236-241. doi: 10.1124/dmd.123.001564. Drug Metab Dispos. 2024. PMID: 38123963

8

Drug Transporters in Xenobiotic Disposition and Pharmacokinetic Prediction.

Mao Q, Lai Y, Wang J. Mao Q, et al. Among authors: lai y. Drug Metab Dispos. 2018 May;46(5):561-566. doi: 10.1124/dmd.118.081356. Drug Metab Dispos. 2018. PMID: 29636376 Free PMC article.

9

Endogenous Plasma Kynurenic Acid in Human: A Newly Discovered Biomarker for Drug-Drug Interactions Involving Organic Anion Transporter 1 and 3 Inhibition.

Tang J, Shen H, Zhao X, Holenarsipur VK, Mariappan TT, Zhang Y, Panfen E, Zheng J, Humphreys WG, Lai Y. Tang J, et al. Among authors: lai y. Drug Metab Dispos. 2021 Dec;49(12):1063-1069. doi: 10.1124/dmd.121.000486. Epub 2021 Oct 1. Drug Metab Dispos. 2021. PMID: 34599018

10

Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium.

Chu X, Liao M, Shen H, Yoshida K, Zur AA, Arya V, Galetin A, Giacomini KM, Hanna I, Kusuhara H, Lai Y, Rodrigues D, Sugiyama Y, Zamek-Gliszczynski MJ, Zhang L; International Transporter Consortium. Chu X, et al. Among authors: lai y. Clin Pharmacol Ther. 2018 Nov;104(5):836-864. doi: 10.1002/cpt.1216. Clin Pharmacol Ther. 2018. PMID: 30347454 Review.

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