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5-(Perylen-3-ylethynyl)uracil as an antiviral scaffold: Potent suppression of enveloped virus reproduction by 3-methyl derivatives in vitro.
Chistov AA, Chumakov SP, Mikhnovets IE, Nikitin TD, Slesarchuk NA, Uvarova VI, Rubekina AA, Nikolaeva YV, Radchenko EV, Khvatov EV, Orlov AA, Frolenko VS, Sukhorukov MV, Kolpakova ES, Shustova EY, Galochkina AV, Streshnev PP, Osipov EM, Sapozhnikova KA, Moiseenko AV, Brylev VA, Proskurin GV, Dokukin YS, Kutyakov SV, Aralov AV, Korshun VA, Strelkov SV, Palyulin VA, Ishmukhametov AA, Shirshin EA, Osolodkin DI, Shtro AA, Kozlovskaya LI, Alferova VA, Ustinov AV. Chistov AA, et al. Among authors: frolenko vs. Antiviral Res. 2023 Jan;209:105508. doi: 10.1016/j.antiviral.2022.105508. Epub 2022 Dec 26. Antiviral Res. 2023. PMID: 36581049
Tetrahydroquinazoline N-oxide derivatives inhibit reproduction of tick-borne and mosquito-borne flaviviruses.
Sedenkova KN, Uvarova VI, Nazarova AA, Peisikova AV, Khvatov EV, Sukhorukov MV, Frolenko VS, Goryashchenko AS, Kholodilov IS, Grishin YK, Rybakov VB, Makenov MT, Morozkin ES, Karan LS, Kozlovskaya LI, Ishmukhametov AA, Osolodkin DI, Averina EB. Sedenkova KN, et al. Among authors: frolenko vs. Arch Pharm (Weinheim). 2023 Jul;356(7):e2300027. doi: 10.1002/ardp.202300027. Epub 2023 May 3. Arch Pharm (Weinheim). 2023. PMID: 37138375
Elongation of N6-benzyladenosine scaffold via Pd-catalyzed C-C bond formation leads to derivatives with antiflaviviral activity.
Zenchenko AA, Drenichev MS, Khvatov EV, Uvarova VI, Goryashchenko AS, Frolenko VS, Karpova EV, Kozlovskaya LI, Osolodkin DI, Ishmukhametov AA, Mikhailov SN, Oslovsky VE. Zenchenko AA, et al. Among authors: frolenko vs. Bioorg Med Chem. 2024 Jan 15;98:117552. doi: 10.1016/j.bmc.2023.117552. Epub 2023 Dec 10. Bioorg Med Chem. 2024. PMID: 38128296