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Engineering an inhibitor-resistant human CSF1R variant for microglia replacement.
Chadarevian JP, Lombroso SI, Peet GC, Hasselmann J, Tu C, Marzan DE, Capocchi J, Purnell FS, Nemec KM, Lahian A, Escobar A, England W, Chaluvadi S, O'Brien CA, Yaqoob F, Aisenberg WH, Porras-Paniagua M, Bennett ML, Davtyan H, Spitale RC, Blurton-Jones M, Bennett FC. Chadarevian JP, et al. Among authors: marzan de. J Exp Med. 2023 Mar 6;220(3):e20220857. doi: 10.1084/jem.20220857. Epub 2022 Dec 30. J Exp Med. 2023. PMID: 36584406 Free PMC article.
Activated microglia drive demyelination via CSF1R signaling.
Marzan DE, Brügger-Verdon V, West BL, Liddelow S, Samanta J, Salzer JL. Marzan DE, et al. Glia. 2021 Jun;69(6):1583-1604. doi: 10.1002/glia.23980. Epub 2021 Feb 23. Glia. 2021. PMID: 33620118 Free PMC article.