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Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.
Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, Wong F, Azad NS, Rucki AA, Laheru D, Donehower R, Zaheer A, Fisher GA, Crocenzi TS, Lee JJ, Greten TF, Duffy AG, Ciombor KK, Eyring AD, Lam BH, Joe A, Kang SP, Holdhoff M, Danilova L, Cope L, Meyer C, Zhou S, Goldberg RM, Armstrong DK, Bever KM, Fader AN, Taube J, Housseau F, Spetzler D, Xiao N, Pardoll DM, Papadopoulos N, Kinzler KW, Eshleman JR, Vogelstein B, Anders RA, Diaz LA Jr. Le DT, et al. Among authors: lu s. Science. 2017 Jul 28;357(6349):409-413. doi: 10.1126/science.aan6733. Epub 2017 Jun 8. Science. 2017. PMID: 28596308 Free PMC article. Clinical Trial.
The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer.
Mattox AK, Douville C, Wang Y, Popoli M, Ptak J, Silliman N, Dobbyn L, Schaefer J, Lu S, Pearlman AH, Cohen JD, Tie J, Gibbs P, Lahouel K, Bettegowda C, Hruban RH, Tomasetti C, Jiang P, Chan KCA, Lo YMD, Papadopoulos N, Kinzler KW, Vogelstein B. Mattox AK, et al. Among authors: lu s. Cancer Discov. 2023 Oct 5;13(10):2166-2179. doi: 10.1158/2159-8290.CD-21-1252. Cancer Discov. 2023. PMID: 37565753 Free PMC article.
Analysis of Shared Variants between Cancer Biospecimens.
Foote MB, White JR, Chatila WK, Argilés G, Lu S, Rousseau B, Artz O, Johannet P, Walch H, Patel M, Lamendola-Essel MF, Casadevall D, Abdelfattah S, Patel S, Yaeger R, Cercek A, Montagut C, Berger M, Schultz N, Diaz LA Jr. Foote MB, et al. Among authors: lu s. Clin Cancer Res. 2025 Jan 17;31(2):376-386. doi: 10.1158/1078-0432.CCR-24-1583. Clin Cancer Res. 2025. PMID: 39561276
Noninvasive Detection of Microsatellite Instability and High Tumor Mutation Burden in Cancer Patients Treated with PD-1 Blockade.
Georgiadis A, Durham JN, Keefer LA, Bartlett BR, Zielonka M, Murphy D, White JR, Lu S, Verner EL, Ruan F, Riley D, Anders RA, Gedvilaite E, Angiuoli S, Jones S, Velculescu VE, Le DT, Diaz LA Jr, Sausen M. Georgiadis A, et al. Among authors: lu s. Clin Cancer Res. 2019 Dec 1;25(23):7024-7034. doi: 10.1158/1078-0432.CCR-19-1372. Epub 2019 Sep 10. Clin Cancer Res. 2019. PMID: 31506389 Free PMC article.
The Spectrum of Benefit from Checkpoint Blockade in Hypermutated Tumors.
Rousseau B, Foote MB, Maron SB, Diplas BH, Lu S, Argilés G, Cercek A, Diaz LA Jr. Rousseau B, et al. Among authors: lu s. N Engl J Med. 2021 Mar 25;384(12):1168-1170. doi: 10.1056/NEJMc2031965. N Engl J Med. 2021. PMID: 33761214 Free PMC article. No abstract available.
DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity.
Lu C, Guan J, Lu S, Jin Q, Rousseau B, Lu T, Stephens D, Zhang H, Zhu J, Yang M, Ren Z, Liang Y, Liu Z, Han C, Liu L, Cao X, Zhang A, Qiao J, Batten K, Chen M, Castrillon DH, Wang T, Li B, Diaz LA Jr, Li GM, Fu YX. Lu C, et al. Among authors: lu s, lu t. Cancer Cell. 2021 Jan 11;39(1):96-108.e6. doi: 10.1016/j.ccell.2020.11.006. Epub 2020 Dec 17. Cancer Cell. 2021. PMID: 33338425 Free PMC article.
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