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[1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes.
Murthy S, Nizi MG, Maksimainen MM, Massari S, Alaviuhkola J, Lippok BE, Vagaggini C, Sowa ST, Galera-Prat A, Ashok Y, Venkannagari H, Prunskaite-Hyyryläinen R, Dreassi E, Lüscher B, Korn P, Tabarrini O, Lehtiö L. Murthy S, et al. Among authors: nizi mg. J Med Chem. 2023 Jan 26;66(2):1301-1320. doi: 10.1021/acs.jmedchem.2c01460. Epub 2023 Jan 4. J Med Chem. 2023. PMID: 36598465 Free PMC article.
Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors.
Nizi MG, Desantis J, Nakatani Y, Massari S, Mazzarella MA, Shetye G, Sabatini S, Barreca ML, Manfroni G, Felicetti T, Rushton-Green R, Hards K, Latacz G, Satała G, Bojarski AJ, Cecchetti V, Kolář MH, Handzlik J, Cook GM, Franzblau SG, Tabarrini O. Nizi MG, et al. Eur J Med Chem. 2020 Sep 1;201:112420. doi: 10.1016/j.ejmech.2020.112420. Epub 2020 Jun 5. Eur J Med Chem. 2020. PMID: 32526553
Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase.
Massari S, Bertagnin C, Pismataro MC, Donnadio A, Nannetti G, Felicetti T, Di Bona S, Nizi MG, Tensi L, Manfroni G, Loza MI, Sabatini S, Cecchetti V, Brea J, Goracci L, Loregian A, Tabarrini O. Massari S, et al. Among authors: nizi mg. Eur J Med Chem. 2021 Jan 1;209:112944. doi: 10.1016/j.ejmech.2020.112944. Epub 2020 Oct 16. Eur J Med Chem. 2021. PMID: 33328103 Free PMC article.
1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors.
Pismataro MC, Felicetti T, Bertagnin C, Nizi MG, Bonomini A, Barreca ML, Cecchetti V, Jochmans D, De Jonghe S, Neyts J, Loregian A, Tabarrini O, Massari S. Pismataro MC, et al. Among authors: nizi mg. Eur J Med Chem. 2021 Oct 5;221:113494. doi: 10.1016/j.ejmech.2021.113494. Epub 2021 Apr 26. Eur J Med Chem. 2021. PMID: 33962311
Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity.
Nizi MG, Persoons L, Corona A, Felicetti T, Cernicchi G, Massari S, Manfroni G, Vangeel L, Barreca ML, Esposito F, Jochmans D, Milia J, Cecchetti V, Schols D, Neyts J, Tramontano E, Sabatini S, De Jonghe S, Tabarrini O. Nizi MG, et al. ACS Med Chem Lett. 2022 May 3;13(5):855-864. doi: 10.1021/acsmedchemlett.2c00123. eCollection 2022 May 12. ACS Med Chem Lett. 2022. PMID: 35571875 Free PMC article.
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