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Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters.
Palomer E, Martín-Flores N, Jolly S, Pascual-Vargas P, Benvegnù S, Podpolny M, Teo S, Vaher K, Saito T, Saido TC, Whiting P, Salinas PC. Palomer E, et al. Among authors: jolly s. Mol Psychiatry. 2022 Jul;27(7):3024-3033. doi: 10.1038/s41380-022-01492-z. Epub 2022 Mar 16. Mol Psychiatry. 2022. PMID: 35296808 Free PMC article.
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
Willis NJ, Mahy W, Sipthorp J, Zhao Y, Woodward HL, Atkinson BN, Bayle ED, Svensson F, Frew S, Jeganathan F, Monaghan A, Benvegnù S, Jolly S, Vecchia L, Ruza RR, Kjær S, Howell S, Snijders AP, Bictash M, Salinas PC, Vincent JP, Jones EY, Whiting P, Fish PV. Willis NJ, et al. Among authors: jolly s. J Med Chem. 2022 May 26;65(10):7212-7230. doi: 10.1021/acs.jmedchem.2c00162. Epub 2022 May 10. J Med Chem. 2022. PMID: 35536179 Free PMC article.
Small-molecule inhibitors of carboxylesterase Notum.
Zhao Y, Jolly S, Benvegnu S, Jones EY, Fish PV. Zhao Y, et al. Among authors: jolly s. Future Med Chem. 2021 Jun;13(11):1001-1015. doi: 10.4155/fmc-2021-0036. Epub 2021 Apr 22. Future Med Chem. 2021. PMID: 33882714 Free PMC article. Review.
709 results