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Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors.
Vieider L, Romp E, Temml V, Fischer J, Kretzer C, Schoenthaler M, Taha A, Hernández-Olmos V, Sturm S, Schuster D, Werz O, Garscha U, Matuszczak B. Vieider L, et al. Among authors: werz o. ACS Med Chem Lett. 2018 Nov 29;10(1):62-66. doi: 10.1021/acsmedchemlett.8b00415. eCollection 2019 Jan 10. ACS Med Chem Lett. 2018. PMID: 30655948 Free PMC article.
Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome.
Werner M, Jordan PM, Romp E, Czapka A, Rao Z, Kretzer C, Koeberle A, Garscha U, Pace S, Claesson HE, Serhan CN, Werz O, Gerstmeier J. Werner M, et al. Among authors: werz o. FASEB J. 2019 May;33(5):6140-6153. doi: 10.1096/fj.201802509R. Epub 2019 Feb 8. FASEB J. 2019. PMID: 30735438 Free PMC article.
M., Romp, E., Czapka, A., Rao, Z., Kretzer, C., Koeberle, A., Garscha, U., Pace, S., Claesson, H.-E., Serhan, C. N., Werz, O., Gerstmeier, J. Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome....
M., Romp, E., Czapka, A., Rao, Z., Kretzer, C., Koeberle, A., Garscha, U., Pace, S., Claesson, H.-E., Serhan, C. N., Werz, O., …
Novel benzoxanthene lignans that favorably modulate lipid mediator biosynthesis: A promising pharmacological strategy for anti-inflammatory therapy.
Gerstmeier J, Kretzer C, Di Micco S, Miek L, Butschek H, Cantone V, Bilancia R, Rizza R, Troisi F, Cardullo N, Tringali C, Ialenti A, Rossi A, Bifulco G, Werz O, Pace S. Gerstmeier J, et al. Among authors: werz o. Biochem Pharmacol. 2019 Jul;165:263-274. doi: 10.1016/j.bcp.2019.03.003. Epub 2019 Mar 2. Biochem Pharmacol. 2019. PMID: 30836057
Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity.
Shkodra-Pula B, Kretzer C, Jordan PM, Klemm P, Koeberle A, Pretzel D, Banoglu E, Lorkowski S, Wallert M, Höppener S, Stumpf S, Vollrath A, Schubert S, Werz O, Schubert US. Shkodra-Pula B, et al. Among authors: werz o. J Nanobiotechnology. 2020 May 14;18(1):73. doi: 10.1186/s12951-020-00620-7. J Nanobiotechnology. 2020. PMID: 32408877 Free PMC article.
Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators.
Pace S, Zhang K, Jordan PM, Bilancia R, Wang W, Börner F, Hofstetter RK, Potenza M, Kretzer C, Gerstmeier J, Fischer D, Lorkowski S, Gilbert NC, Newcomer ME, Rossi A, Chen X, Werz O. Pace S, et al. Among authors: werz o. Pharmacol Res. 2021 May;167:105556. doi: 10.1016/j.phrs.2021.105556. Epub 2021 Mar 31. Pharmacol Res. 2021. PMID: 33812006
422 results