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Cryptosporidium PI(4)K inhibitor EDI048 is a gut-restricted parasiticidal agent to treat paediatric enteric cryptosporidiosis.
Manjunatha UH, Lakshminarayana SB, Jumani RS, Chao AT, Young JM, Gable JE, Knapp M, Hanna I, Galarneau JR, Cantwell J, Kulkarni U, Turner M, Lu P, Darrell KH, Watson LC, Chan K, Patra D, Mamo M, Luu C, Cuellar C, Shaul J, Xiao L, Chen YB, Carney SK, Lakshman J, Osborne CS, Zambriski JA, Aziz N, Sarko C, Diagana TT. Manjunatha UH, et al. Among authors: young jm. Nat Microbiol. 2024 Nov;9(11):2817-2835. doi: 10.1038/s41564-024-01810-x. Epub 2024 Oct 8. Nat Microbiol. 2024. PMID: 39379634 Free PMC article.
Recognition of phylogenetically diverse pathogens through enzymatically amplified recruitment of RNF213.
Crespillo-Casado A, Pothukuchi P, Naydenova K, Yip MCJ, Young JM, Boulanger J, Dharamdasani V, Harper C, Hammoudi PM, Otten EG, Boyle K, Gogoi M, Malik HS, Randow F. Crespillo-Casado A, et al. Among authors: young jm. EMBO Rep. 2024 Nov;25(11):4979-5005. doi: 10.1038/s44319-024-00280-w. Epub 2024 Oct 7. EMBO Rep. 2024. PMID: 39375464 Free PMC article.
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