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Anticancer Properties of Hexosamine Analogs Designed to Attenuate Metabolic Flux through the Hexosamine Biosynthetic Pathway.
Saeui CT, Shah SR, Fernandez-Gil BI, Zhang C, Agatemor C, Dammen-Brower K, Mathew MP, Buettner M, Gowda P, Khare P, Otamendi-Lopez A, Yang S, Zhang H, Le A, Quinoñes-Hinojosa A, Yarema KJ. Saeui CT, et al. Among authors: khare p. ACS Chem Biol. 2023 Jan 20;18(1):151-165. doi: 10.1021/acschembio.2c00784. Epub 2023 Jan 10. ACS Chem Biol. 2023. PMID: 36626752
A specialized metabolic pathway partitions citrate in hydroxyapatite to impact mineralization of bones and teeth.
Dirckx N, Zhang Q, Chu EY, Tower RJ, Li Z, Guo S, Yuan S, Khare PA, Zhang C, Verardo A, Alejandro LO, Park A, Faugere MC, Helfand SL, Somerman MJ, Riddle RC, de Cabo R, Le A, Schmidt-Rohr K, Clemens TL. Dirckx N, et al. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2212178119. doi: 10.1073/pnas.2212178119. Epub 2022 Nov 2. Proc Natl Acad Sci U S A. 2022. PMID: 36322718 Free PMC article.
Cancer cells employ lipid droplets to survive toxic stress.
Kostecka LG, Mendez S, Li M, Khare P, Zhang C, Le A, Amend SR, Pienta KJ. Kostecka LG, et al. Among authors: khare p. Prostate. 2024 May;84(7):644-655. doi: 10.1002/pros.24680. Epub 2024 Feb 26. Prostate. 2024. PMID: 38409853
Excoriation Disorder Is Characterized by Systemic Glutamatergic Dysfunction.
Bordeaux ZA, Reddy SV, Ma EZ, Cornman H, Pritchard T, Marani M, Lu W, Guo S, Zhang C, Khare P, Le A, Kwatra MM, Kwatra SG. Bordeaux ZA, et al. Among authors: khare p. J Invest Dermatol. 2024 Sep;144(9):2085-2089.e1. doi: 10.1016/j.jid.2024.02.005. Epub 2024 Mar 4. J Invest Dermatol. 2024. PMID: 38447865 No abstract available.
Dual treatment with kynurenine pathway inhibitors and NAD+ precursors synergistically extends life span in Drosophila.
Gabrawy MM, Westbrook R, King A, Khosravian N, Ochaney N, DeCarvalho T, Wang Q, Yu Y, Huang Q, Said A, Abadir M, Zhang C, Khare P, Fairman JE, Le A, Milne GL, Vonhoff FJ, Walston JD, Abadir PM. Gabrawy MM, et al. Among authors: khare p. Aging Cell. 2024 Apr;23(4):e14102. doi: 10.1111/acel.14102. Epub 2024 Mar 13. Aging Cell. 2024. PMID: 38481042 Free PMC article.
313 results