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Page 1
Covalent small molecule inhibitors of Ca(2+)-bound S100B.
Cavalier MC, Pierce AD, Wilder PT, Alasady MJ, Hartman KG, Neau DB, Foley TL, Jadhav A, Maloney DJ, Simeonov A, Toth EA, Weber DJ. Cavalier MC, et al. Among authors: alasady mj. Biochemistry. 2014 Oct 28;53(42):6628-40. doi: 10.1021/bi5005552. Epub 2014 Oct 14. Biochemistry. 2014. PMID: 25268459 Free PMC article.
Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations.
Cavalier MC, Ansari MI, Pierce AD, Wilder PT, McKnight LE, Raman EP, Neau DB, Bezawada P, Alasady MJ, Charpentier TH, Varney KM, Toth EA, MacKerell AD Jr, Coop A, Weber DJ. Cavalier MC, et al. Among authors: alasady mj. J Med Chem. 2016 Jan 28;59(2):592-608. doi: 10.1021/acs.jmedchem.5b01369. Epub 2016 Jan 13. J Med Chem. 2016. PMID: 26727270 Free PMC article.
The Multifaceted Role of HSF1 in Tumorigenesis.
Alasady MJ, Mendillo ML. Alasady MJ, et al. Adv Exp Med Biol. 2020;1243:69-85. doi: 10.1007/978-3-030-40204-4_5. Adv Exp Med Biol. 2020. PMID: 32297212 Free PMC article. Review.
HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state.
Smith RS, Takagishi SR, Amici DR, Metz K, Gayatri S, Alasady MJ, Wu Y, Brockway S, Taiberg SL, Khalatyan N, Taipale M, Santagata S, Whitesell L, Lindquist S, Savas JN, Mendillo ML. Smith RS, et al. Among authors: alasady mj. Sci Adv. 2022 Mar 18;8(11):eabj6526. doi: 10.1126/sciadv.abj6526. Epub 2022 Mar 16. Sci Adv. 2022. PMID: 35294249 Free PMC article.
Octopamine metabolically reprograms astrocytes to confer neuroprotection against α-synuclein.
Shum A, Zaichick S, McElroy GS, D'Alessandro K, Alasady MJ, Novakovic M, Peng W, Grebenik EA, Chung D, Flanagan ME, Smith R, Morales A, Stumpf L, McGrath K, Krainc D, Mendillo ML, Prakriya M, Chandel NS, Caraveo G. Shum A, et al. Among authors: alasady mj. Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e2217396120. doi: 10.1073/pnas.2217396120. Epub 2023 Apr 17. Proc Natl Acad Sci U S A. 2023. PMID: 37068235 Free PMC article.
Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life.
Amici DR, Alhayek S, Klein AT, Wang YZ, Wilen AP, Song W, Zhu P, Thakkar A, King MA, Steffeck AW, Alasady MJ, Peek C, Savas JN, Mendillo ML. Amici DR, et al. Among authors: alasady mj. Life Sci Alliance. 2024 Mar 7;7(5):e202302370. doi: 10.26508/lsa.202302370. Print 2024 May. Life Sci Alliance. 2024. PMID: 38453366 Free PMC article.
An HSF1-JMJD6-HSP feedback circuit promotes cell adaptation to proteotoxic stress.
Alasady MJ, Koeva M, Takagishi SR, Segal D, Amici DR, Smith RS, Ansel DJ, Lindquist S, Whitesell L, Bartom ET, Taipale M, Mendillo ML. Alasady MJ, et al. Proc Natl Acad Sci U S A. 2024 Jul 16;121(29):e2313370121. doi: 10.1073/pnas.2313370121. Epub 2024 Jul 10. Proc Natl Acad Sci U S A. 2024. PMID: 38985769 Free PMC article.
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