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Transcriptional reprogramming restores UBE3A brain-wide and rescues behavioral phenotypes in an Angelman syndrome mouse model.
O'Geen H, Beitnere U, Garcia MS, Adhikari A, Cameron DL, Fenton TA, Copping NA, Deng P, Lock S, Halmai JANM, Villegas IJ, Liu J, Wang D, Fink KD, Silverman JL, Segal DJ. O'Geen H, et al. Among authors: segal dj. Mol Ther. 2023 Apr 5;31(4):1088-1105. doi: 10.1016/j.ymthe.2023.01.013. Epub 2023 Jan 14. Mol Ther. 2023. PMID: 36641623 Free PMC article.
Integration of CTCF loops, methylome, and transcriptome in differentiating LUHMES as a model for imprinting dynamics of the 15q11-q13 locus in human neurons.
Gutierrez Fugón OJ, Sharifi O, Heath N, Soto DC, Gomez JA, Yasui DH, Mendiola AJP, O'Geen H, Beitnere U, Tomkova M, Haghani V, Dillon G, Segal DJ, LaSalle JM. Gutierrez Fugón OJ, et al. Among authors: segal dj. Hum Mol Genet. 2024 Sep 19;33(19):1711-1725. doi: 10.1093/hmg/ddae111. Hum Mol Genet. 2024. PMID: 39045627 Free PMC article.
Beyond the genome and into the clinic.
Segal DJ. Segal DJ. Genome Med. 2012 Oct 30;4(10):78. doi: 10.1186/gm379. eCollection 2012. Genome Med. 2012. PMID: 23114014 Free PMC article.
Editorial: Precise Genome Editing Techniques and Applications.
Xu K, Segal DJ, Zhang Z. Xu K, et al. Among authors: segal dj. Front Genet. 2020 Apr 21;11:412. doi: 10.3389/fgene.2020.00412. eCollection 2020. Front Genet. 2020. PMID: 32373168 Free PMC article. No abstract available.
120 results