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Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice.
Endo S, Nakata K, Ohuchida K, Takesue S, Nakayama H, Abe T, Koikawa K, Okumura T, Sada M, Horioka K, Zheng B, Mizuuchi Y, Iwamoto C, Murata M, Moriyama T, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M. Endo S, et al. Among authors: sada m. Gastroenterology. 2017 May;152(6):1492-1506.e24. doi: 10.1053/j.gastro.2017.01.010. Epub 2017 Jan 23. Gastroenterology. 2017. PMID: 28126348
Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing the invasiveness of pancreatic cancer cells.
Okumura T, Ohuchida K, Sada M, Abe T, Endo S, Koikawa K, Iwamoto C, Miura D, Mizuuchi Y, Moriyama T, Nakata K, Miyasaka Y, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Oda Y, Hashizume M, Nakamura M. Okumura T, et al. Among authors: sada m. Oncotarget. 2017 Mar 14;8(11):18280-18295. doi: 10.18632/oncotarget.15430. Oncotarget. 2017. PMID: 28407685 Free PMC article.
Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180.
Koikawa K, Ohuchida K, Takesue S, Ando Y, Kibe S, Nakayama H, Endo S, Abe T, Okumura T, Horioka K, Sada M, Iwamoto C, Moriyama T, Nakata K, Miyasaka Y, Ohuchida R, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M. Koikawa K, et al. Among authors: sada m. Cancer Lett. 2018 Jan 1;412:143-154. doi: 10.1016/j.canlet.2017.10.010. Epub 2017 Oct 20. Cancer Lett. 2018. PMID: 29061505
Adipose tissue-derived stromal cells are sources of cancer-associated fibroblasts and enhance tumor progression by dense collagen matrix.
Okumura T, Ohuchida K, Kibe S, Iwamoto C, Ando Y, Takesue S, Nakayama H, Abe T, Endo S, Koikawa K, Sada M, Horioka K, Mochidome N, Arita M, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M. Okumura T, et al. Among authors: sada m. Int J Cancer. 2019 Mar 15;144(6):1401-1413. doi: 10.1002/ijc.31775. Epub 2018 Oct 10. Int J Cancer. 2019. PMID: 30152542
217 results