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Depletion of the RNA-binding protein PURA triggers changes in posttranscriptional gene regulation and loss of P-bodies.
Molitor L, Klostermann M, Bacher S, Merl-Pham J, Spranger N, Burczyk S, Ketteler C, Rusha E, Tews D, Pertek A, Proske M, Busch A, Reschke S, Feederle R, Hauck SM, Blum H, Drukker M, Fischer-Posovszky P, König J, Zarnack K, Niessing D. Molitor L, et al. Nucleic Acids Res. 2023 Feb 22;51(3):1297-1316. doi: 10.1093/nar/gkac1237. Nucleic Acids Res. 2023. PMID: 36651277 Free PMC article.
Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene.
Wabitsch M, Funcke JB, von Schnurbein J, Denzer F, Lahr G, Mazen I, El-Gammal M, Denzer C, Moss A, Debatin KM, Gierschik P, Mistry V, Keogh JM, Farooqi IS, Moepps B, Fischer-Posovszky P. Wabitsch M, et al. J Clin Endocrinol Metab. 2015 Sep;100(9):3227-30. doi: 10.1210/jc.2015-2263. Epub 2015 Jul 17. J Clin Endocrinol Metab. 2015. PMID: 26186301 Free PMC article.
MicroRNA-221-3p Regulates Angiopoietin-Like 8 (ANGPTL8) Expression in Adipocytes.
Mysore R, Ortega FJ, Latorre J, Ahonen M, Savolainen-Peltonen H, Fischer-Posovszky P, Wabitsch M, Olkkonen VM, Fernández-Real JM, Haridas PAN. Mysore R, et al. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4001-4012. doi: 10.1210/jc.2017-00453. J Clin Endocrinol Metab. 2017. PMID: 28938482
MicroRNA-192* impairs adipocyte triglyceride storage.
Mysore R, Zhou Y, Sädevirta S, Savolainen-Peltonen H, Nidhina Haridas PA, Soronen J, Leivonen M, Sarin AP, Fischer-Posovszky P, Wabitsch M, Yki-Järvinen H, Olkkonen VM. Mysore R, et al. Biochim Biophys Acta. 2016 Apr;1861(4):342-51. doi: 10.1016/j.bbalip.2015.12.019. Epub 2015 Dec 30. Biochim Biophys Acta. 2016. PMID: 26747651
Human adipocyte differentiation and composition of disease-relevant lipids are regulated by miR-221-3p.
Ahonen MA, Asghar MY, Parviainen SJ, Liebisch G, Höring M, Leidenius M, Fischer-Posovszky P, Wabitsch M, Mikkola TS, Törnquist K, Savolainen-Peltonen H, Haridas PAN, Olkkonen VM. Ahonen MA, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Jan;1866(1):158841. doi: 10.1016/j.bbalip.2020.158841. Epub 2020 Oct 16. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 33075494
T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance.
Kintscher U, Hartge M, Hess K, Foryst-Ludwig A, Clemenz M, Wabitsch M, Fischer-Posovszky P, Barth TF, Dragun D, Skurk T, Hauner H, Blüher M, Unger T, Wolf AM, Knippschild U, Hombach V, Marx N. Kintscher U, et al. Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1304-10. doi: 10.1161/ATVBAHA.108.165100. Epub 2008 Apr 17. Arterioscler Thromb Vasc Biol. 2008. PMID: 18420999
Estimated prevalence of potentially damaging variants in the leptin gene.
Nunziata A, Borck G, Funcke JB, Kohlsdorf K, Brandt S, Hinney A, Moepps B, Gierschik P, Debatin KM, Fischer-Posovszky P, Wabitsch M. Nunziata A, et al. Mol Cell Pediatr. 2017 Nov 3;4(1):10. doi: 10.1186/s40348-017-0074-x. Mol Cell Pediatr. 2017. PMID: 29101506 Free PMC article.
[Lipodystrophies].
Fischer-Posovszky P, Debatin KM, Wabitsch M. Fischer-Posovszky P, et al. Klin Padiatr. 2002 May-Jun;214(3):99-103. doi: 10.1055/s-2002-30142. Klin Padiatr. 2002. PMID: 12015640 Review. German.
125 results