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27 results

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Page 1
Therapeutic Trial of anle138b in Mouse Models of Genetic Prion Disease.
Vallabh SM, Zou D, Pitstick R, O'Moore J, Peters J, Silvius D, Kriz J, Jackson WS, Carlson GA, Minikel EV, Cabin DE. Vallabh SM, et al. Among authors: cabin de. J Virol. 2023 Feb 28;97(2):e0167222. doi: 10.1128/jvi.01672-22. Epub 2023 Jan 18. J Virol. 2023. PMID: 36651748 Free PMC article.
Antisense oligonucleotides extend survival of prion-infected mice.
Raymond GJ, Zhao HT, Race B, Raymond LD, Williams K, Swayze EE, Graffam S, Le J, Caron T, Stathopoulos J, O'Keefe R, Lubke LL, Reidenbach AG, Kraus A, Schreiber SL, Mazur C, Cabin DE, Carroll JB, Minikel EV, Kordasiewicz H, Caughey B, Vallabh SM. Raymond GJ, et al. Among authors: cabin de. JCI Insight. 2019 Jul 30;5(16):e131175. doi: 10.1172/jci.insight.131175. JCI Insight. 2019. PMID: 31361599 Free PMC article.
Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints.
Minikel EV, Zhao HT, Le J, O'Moore J, Pitstick R, Graffam S, Carlson GA, Kavanaugh MP, Kriz J, Kim JB, Ma J, Wille H, Aiken J, McKenzie D, Doh-Ura K, Beck M, O'Keefe R, Stathopoulos J, Caron T, Schreiber SL, Carroll JB, Kordasiewicz HB, Cabin DE, Vallabh SM. Minikel EV, et al. Among authors: cabin de. Nucleic Acids Res. 2020 Nov 4;48(19):10615-10631. doi: 10.1093/nar/gkaa616. Nucleic Acids Res. 2020. PMID: 32776089 Free PMC article.
Regional variability and genotypic and pharmacodynamic effects on PrP concentration in the CNS.
Mortberg MA, Zhao HT, Reidenbach AG, Gentile JE, Kuhn E, O'Moore J, Dooley PM, Connors TR, Mazur C, Allen SW, Trombetta BA, McManus A, Moore MR, Liu J, Cabin DE, Kordasiewicz HB, Mathews J, Arnold SE, Vallabh SM, Minikel EV. Mortberg MA, et al. Among authors: cabin de. JCI Insight. 2022 Mar 22;7(6):e156532. doi: 10.1172/jci.insight.156532. JCI Insight. 2022. PMID: 35133987 Free PMC article.
PrP turnover in vivo and the time to effect of prion disease therapeutics.
Corridon TL, O'Moore J, Lian Y, Laversenne V, Noble B, Kamath NG, Serack FE, Shaikh AB, Erickson B, Braun C, Lenz K, Howard M, Chan N, Reidenbach AG, Cabin DE, Vallabh SM, Grindeland A, Oberbeck N, Zhao HT, Minikel EV. Corridon TL, et al. Among authors: cabin de. bioRxiv [Preprint]. 2024 Nov 14:2024.11.12.623215. doi: 10.1101/2024.11.12.623215. bioRxiv. 2024. PMID: 39605733 Free PMC article. Preprint.
Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration.
Fanara P, Wong PY, Husted KH, Liu S, Liu VM, Kohlstaedt LA, Riiff T, Protasio JC, Boban D, Killion S, Killian M, Epling L, Sinclair E, Peterson J, Price RW, Cabin DE, Nussbaum RL, Brühmann J, Brandt R, Christine CW, Aminoff MJ, Hellerstein MK. Fanara P, et al. Among authors: cabin de. J Clin Invest. 2012 Sep;122(9):3159-69. doi: 10.1172/JCI64575. Epub 2012 Aug 27. J Clin Invest. 2012. PMID: 22922254 Free PMC article.
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