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Inactive disease in patients with lupus is linked to autoantibodies to type I interferons that normalize blood IFNα and B cell subsets.
Bradford HF, Haljasmägi L, Menon M, McDonnell TCR, Särekannu K, Vanker M, Peterson P, Wincup C, Abida R, Gonzalez RF, Bondet V, Duffy D, Isenberg DA, Kisand K, Mauri C. Bradford HF, et al. Among authors: isenberg da. Cell Rep Med. 2023 Jan 17;4(1):100894. doi: 10.1016/j.xcrm.2022.100894. Cell Rep Med. 2023. PMID: 36652906 Free PMC article.
IgG anti-endothelial cell autoantibodies from patients with systemic lupus erythematosus or systemic vasculitis stimulate the release of two endothelial cell-derived mediators, which enhance adhesion molecule expression and leukocyte adhesion in an autocrine manner.
Carvalho D, Savage CO, Isenberg D, Pearson JD. Carvalho D, et al. Arthritis Rheum. 1999 Apr;42(4):631-40. doi: 10.1002/1529-0131(199904)42:4<631::AID-ANR5>3.0.CO;2-X. Arthritis Rheum. 1999. PMID: 10211876 Free article.
859 results