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Estrogen Receptor Genes, Cognitive Decline, and Alzheimer Disease.
Oveisgharan S, Yang J, Yu L, Burba D, Bang W, Tasaki S, Grodstein F, Wang Y, Zhao J, De Jager PL, Schneider JA, Bennett DA. Oveisgharan S, et al. Among authors: de jager pl. Neurology. 2023 Apr 4;100(14):e1474-e1487. doi: 10.1212/WNL.0000000000206833. Epub 2023 Jan 25. Neurology. 2023. PMID: 36697247 Free PMC article.
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts.
Zhou W, Karan KR, Gu W, Klein HU, Sturm G, De Jager PL, Bennett DA, Hirano M, Picard M, Mills RE. Zhou W, et al. Among authors: de jager pl. bioRxiv [Preprint]. 2023 Apr 21:2023.02.03.527065. doi: 10.1101/2023.02.03.527065. bioRxiv. 2023. Update in: PLoS Biol. 2024 Aug 22;22(8):e3002723. doi: 10.1371/journal.pbio.3002723 PMID: 36778249 Free PMC article. Updated. Preprint.
Multi-omic characterization of brain changes in the vascular endothelial growth factor family during aging and Alzheimer's disease.
Seto M, Dumitrescu L, Mahoney ER, Sclafani AM, De Jager PL, Menon V, Koran MEI, Robinson RA, Ruderfer DM, Cox NJ, Seyfried NT, Jefferson AL, Schneider JA, Bennett DA, Petyuk VA, Hohman TJ. Seto M, et al. Among authors: de jager pl. Neurobiol Aging. 2023 Jun;126:25-33. doi: 10.1016/j.neurobiolaging.2023.01.010. Epub 2023 Jan 26. Neurobiol Aging. 2023. PMID: 36905877 Free PMC article.
Benchmarking of deep neural networks for predicting personal gene expression from DNA sequence highlights shortcomings.
Sasse A, Ng B, Spiro AE, Tasaki S, Bennett DA, Gaiteri C, De Jager PL, Chikina M, Mostafavi S. Sasse A, et al. Among authors: de jager pl. bioRxiv [Preprint]. 2023 Sep 28:2023.03.16.532969. doi: 10.1101/2023.03.16.532969. bioRxiv. 2023. Update in: Nat Genet. 2023 Dec;55(12):2060-2064. doi: 10.1038/s41588-023-01524-6 PMID: 36993652 Free PMC article. Updated. Preprint.
A single-nucleus transcriptome-wide association study implicates novel genes in depression pathogenesis.
Zeng L, Fujita M, Gao Z, White CC, Green GS, Habib N, Menon V, Bennett DA, Boyle PA, Klein HU, De Jager PL. Zeng L, et al. Among authors: de jager pl. medRxiv [Preprint]. 2023 Mar 29:2023.03.27.23286844. doi: 10.1101/2023.03.27.23286844. medRxiv. 2023. Update in: Biol Psychiatry. 2024 Jul 1;96(1):34-43. doi: 10.1016/j.biopsych.2023.12.012 PMID: 37034737 Free PMC article. Updated. Preprint.
Primacy and recency effects in verbal memory are differentially associated with post-mortem frontal cortex p-tau 217 and 202 levels in a mixed sample of community-dwelling older adults.
Gicas KM, Honer WG, Petyuk VA, Wilson RS, Boyle PA, Leurgans SE, Schneider JA, De Jager PL, Bennett DA. Gicas KM, et al. Among authors: de jager pl. J Clin Exp Neuropsychol. 2023 Oct;45(8):770-785. doi: 10.1080/13803395.2023.2232583. Epub 2023 Jul 13. J Clin Exp Neuropsychol. 2023. PMID: 37440260 Free PMC article.
Unbiased classification of the elderly human brain proteome resolves distinct clinical and pathophysiological subtypes of cognitive impairment.
Higginbotham L, Carter EK, Dammer EB, Haque RU, Johnson ECB, Duong DM, Yin L, De Jager PL, Bennett DA, Felsky D, Tio ES, Lah JJ, Levey AI, Seyfried NT. Higginbotham L, et al. Among authors: de jager pl. Neurobiol Dis. 2023 Oct 1;186:106286. doi: 10.1016/j.nbd.2023.106286. Epub 2023 Sep 7. Neurobiol Dis. 2023. PMID: 37689213 Free PMC article.
589 results