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Discovery of Potent and Orally Bioavailable Pyrimidine Amide cGAS Inhibitors via Structure-Guided Hybridization.
Cyr P, Fader LD, Burch JD, Pike KA, Sietsema DV, Boily MO, Ciblat S, Sgarioto N, Skeldon AM, Gaudreault S, Le Gros P, Dumais V, McKay DJJ, Abraham NS, Seliniotakis R, Beveridge RE. Cyr P, et al. Among authors: pike ka. ACS Med Chem Lett. 2024 Nov 25;15(12):2201-2209. doi: 10.1021/acsmedchemlett.4c00471. eCollection 2024 Dec 12. ACS Med Chem Lett. 2024. PMID: 39691514
Patient-centred composite scores as tools for assesment of response to biological therapy for paediatric and adult severe asthma.
Khaleva E, Brightling C, Eiwegger T, Altraja A, Bégin P, Blumchen K, Bossios A, Bourdin A, Ten Brinke A, Brusselle G, Silvia Bumbacea R, Bush A, Casale TB, Clarke GW, Chaudhuri R, Fan Chung K, Coleman C, Corren J, Dahlén SE, Deschildre A, Djukanovic R, Eger K, Exley A, Fleming L, Fowler SJ, Gaillard EA, Gappa M, Gupta A, Michael Haitchi H, Hashimoto S, Heaney LG, Hedlin G, Henderson M, Hua W, Jackson DJ, Karadag B, Helen Katelaris C, Koh MS, Volkmar Kopp M, Koppelman GH, Kull I, Kurukulaaratchy RJ, Lee JH, Mahler V, Mäkelä M, Masoli M, Mathioudakis AG, Mazon A, Melén E, Milger K, Moeller A, Murray CS, Nagakumar P, Nair P, Negus J, Nieto A, Papadopoulos NG, Paton J, Pijnenburg MW, Pike KC, Porsbjerg C, Rattu A, Rupani H, Rusconi F, Rutjes NW, Saglani S, Seddon P, Siddiqui S, Singer F, Tajiri T, Turner S, Upham JW, Vijverberg SJH, Wark PAB, Wechsler ME, Yasinska V, Roberts G. Khaleva E, et al. Among authors: pike kc. Eur Respir J. 2024 Nov 21:2400691. doi: 10.1183/13993003.00691-2024. Online ahead of print. Eur Respir J. 2024. PMID: 39510551 Free article.
456 results