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Structural basis for substrate selection by the SARS-CoV-2 replicase.
Malone BF, Perry JK, Olinares PDB, Lee HW, Chen J, Appleby TC, Feng JY, Bilello JP, Ng H, Sotiris J, Ebrahim M, Chua EYD, Mendez JH, Eng ET, Landick R, Götte M, Chait BT, Campbell EA, Darst SA. Malone BF, et al. Among authors: lee hw. Nature. 2023 Feb;614(7949):781-787. doi: 10.1038/s41586-022-05664-3. Epub 2023 Feb 1. Nature. 2023. PMID: 36725929 Free PMC article.
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.
Stevens LJ, Pruijssers AJ, Lee HW, Gordon CJ, Tchesnokov EP, Gribble J, George AS, Hughes TM, Lu X, Li J, Perry JK, Porter DP, Cihlar T, Sheahan TP, Baric RS, Götte M, Denison MR. Stevens LJ, et al. Among authors: lee hw. Sci Transl Med. 2022 Aug 3;14(656):eabo0718. doi: 10.1126/scitranslmed.abo0718. Epub 2022 Aug 3. Sci Transl Med. 2022. PMID: 35482820 Free PMC article.
SARS-CoV-2 resistance analyses from the Phase 3 PINETREE study of remdesivir treatment in nonhospitalized participants.
Rodriguez L, Lee HW, Li J, Martin R, Han D, Xu S, Moshiri J, Peinovich N, Camus G, Perry JK, Hyland RH, Porter DP, Abdelghany M, Götte M, Hedskog C. Rodriguez L, et al. Among authors: lee hw. Antimicrob Agents Chemother. 2024 Dec 19:e0123824. doi: 10.1128/aac.01238-24. Online ahead of print. Antimicrob Agents Chemother. 2024. PMID: 39699245 Free article.
SLC35A2 modulates paramyxovirus fusion events during infection.
Yang Y, Wang Y, Campbell DE, Lee HW, Beatty W, Wang L, Baldridge M, López CB. Yang Y, et al. Among authors: lee hw. PLoS Pathog. 2025 Jan 10;21(1):e1012531. doi: 10.1371/journal.ppat.1012531. Online ahead of print. PLoS Pathog. 2025. PMID: 39792924
3,634 results