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Page 1
The Effect of FTY720 on Sphingolipid Imbalance and Cognitive Decline in Aged EFAD Mice.
Luo Q, Crivelli SM, Zong S, Giovagnoni C, van Kruining D, Mané-Damas M, den Hoedt S, Berkes D, De Vries HE, Mulder MT, Walter J, Waelkens E, Derua R, Swinnen JV, Dehairs J, Losen M, Martinez-Martinez P. Luo Q, et al. Among authors: den hoedt s. J Alzheimers Dis Rep. 2024 Sep 27;8(1):1317-1327. doi: 10.3233/ADR-230053. eCollection 2024. J Alzheimers Dis Rep. 2024. PMID: 39434823 Free PMC article.
Sphingolipids in Cerebrospinal Fluid and Plasma Lipoproteins of APOE4 Homozygotes and Non-APOE4 Carriers with Mild Cognitive Impairment versus Subjective Cognitive Decline.
den Hoedt S, Dorst-Lagerwerf KY, de Vries HE, Rozemuller AJM, Scheltens P, Walter J, Sijbrands EJG, Martinez-Martinez P, Verhoeven AJM, Teunissen CE, Mulder MT. den Hoedt S, et al. J Alzheimers Dis Rep. 2023 May 3;7(1):339-354. doi: 10.3233/ADR220072. eCollection 2023. J Alzheimers Dis Rep. 2023. PMID: 37220621 Free PMC article.
SMPD4 regulates mitotic nuclear envelope dynamics and its loss causes microcephaly and diabetes.
Smits DJ, Schot R, Krusy N, Wiegmann K, Utermöhlen O, Mulder MT, den Hoedt S, Yoon G, Deshwar AR, Kresge C, Pletcher B, van Mook M, Ferreira MS, Poot RA, Slotman JA, Kremers GJ, Ahmad A, Albash B, Bastaki L, Marafi D, Dekker J, van Ham TJ, Nguyen L, Mancini GMS. Smits DJ, et al. Among authors: den hoedt s. Brain. 2023 Aug 1;146(8):3528-3541. doi: 10.1093/brain/awad033. Brain. 2023. PMID: 36732302 Free PMC article.
A cryogenic, coincident fluorescence, electron, and ion beam microscope.
Boltje DB, Hoogenboom JP, Jakobi AJ, Jensen GJ, Jonker CTH, Kaag MJ, Koster AJ, Last MGF, de Agrela Pinto C, Plitzko JM, Raunser S, Tacke S, Wang Z, van der Wee EB, Wepf R, den Hoedt S. Boltje DB, et al. Among authors: den hoedt s. Elife. 2022 Oct 28;11:e82891. doi: 10.7554/eLife.82891. Elife. 2022. PMID: 36305590 Free PMC article.
FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer's disease expressing APOE4.
Crivelli SM, Luo Q, Kruining DV, Giovagnoni C, Mané-Damas M, den Hoedt S, Berkes D, De Vries HE, Mulder MT, Walter J, Waelkens E, Derua R, Swinnen JV, Dehairs J, Wijnands EPM, Bieberich E, Losen M, Martinez-Martinez P. Crivelli SM, et al. Among authors: den hoedt s. Biomed Pharmacother. 2022 Aug;152:113240. doi: 10.1016/j.biopha.2022.113240. Epub 2022 Jun 9. Biomed Pharmacother. 2022. PMID: 35689862 Free article.
Effects of Sex, Age, and Apolipoprotein E Genotype on Brain Ceramides and Sphingosine-1-Phosphate in Alzheimer's Disease and Control Mice.
den Hoedt S, Crivelli SM, Leijten FPJ, Losen M, Stevens JAA, Mané-Damas M, de Vries HE, Walter J, Mirzaian M, Sijbrands EJG, Aerts JMFG, Verhoeven AJM, Martinez-Martinez P, Mulder MT. den Hoedt S, et al. Front Aging Neurosci. 2021 Oct 27;13:765252. doi: 10.3389/fnagi.2021.765252. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34776936 Free PMC article.
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