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A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan.
Winicki NM, Nanavati AP, Morrell CH, Moen JM, Axsom JE, Krawczyk M, Petrashevskaya NN, Beyman MG, Ramirez C, Alfaras I, Mitchell SJ, Juhaszova M, Riordon DR, Wang M, Zhang J, Cerami A, Brines M, Sollott SJ, de Cabo R, Lakatta EG. Winicki NM, et al. Among authors: mitchell sj. Front Cardiovasc Med. 2023 Jan 18;9:1096887. doi: 10.3389/fcvm.2022.1096887. eCollection 2022. Front Cardiovasc Med. 2023. PMID: 36741836 Free PMC article.
Metformin improves healthspan and lifespan in mice.
Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R. Martin-Montalvo A, et al. Among authors: mitchell sj. Nat Commun. 2013;4:2192. doi: 10.1038/ncomms3192. Nat Commun. 2013. PMID: 23900241 Free PMC article.
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.
Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R. Mercken EM, et al. Among authors: mitchell sj. Aging Cell. 2014 Oct;13(5):787-96. doi: 10.1111/acel.12220. Epub 2014 Jun 16. Aging Cell. 2014. PMID: 24931715 Free PMC article.
Macronutrients and caloric intake in health and longevity.
Solon-Biet SM, Mitchell SJ, de Cabo R, Raubenheimer D, Le Couteur DG, Simpson SJ. Solon-Biet SM, et al. Among authors: mitchell sj. J Endocrinol. 2015 Jul;226(1):R17-28. doi: 10.1530/JOE-15-0173. Epub 2015 May 28. J Endocrinol. 2015. PMID: 26021555 Free PMC article. Review.
Measures of Healthspan as Indices of Aging in Mice-A Recommendation.
Richardson A, Fischer KE, Speakman JR, de Cabo R, Mitchell SJ, Peterson CA, Rabinovitch P, Chiao YA, Taffet G, Miller RA, Rentería RC, Bower J, Ingram DK, Ladiges WC, Ikeno Y, Sierra F, Austad SN. Richardson A, et al. Among authors: mitchell sj. J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):427-30. doi: 10.1093/gerona/glv080. Epub 2015 Aug 22. J Gerontol A Biol Sci Med Sci. 2016. PMID: 26297941 Free PMC article.
Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type.
Kane AE, Mitchell SJ, Mach J, Huizer-Pajkos A, McKenzie C, Jones B, Cogger V, Le Couteur DG, de Cabo R, Hilmer SN. Kane AE, et al. Among authors: mitchell sj. Exp Gerontol. 2016 Jan;73:95-106. doi: 10.1016/j.exger.2015.11.013. Epub 2015 Nov 23. Exp Gerontol. 2016. PMID: 26615879 Free PMC article.
The impact of low-protein high-carbohydrate diets on aging and lifespan.
Le Couteur DG, Solon-Biet S, Cogger VC, Mitchell SJ, Senior A, de Cabo R, Raubenheimer D, Simpson SJ. Le Couteur DG, et al. Among authors: mitchell sj. Cell Mol Life Sci. 2016 Mar;73(6):1237-52. doi: 10.1007/s00018-015-2120-y. Epub 2015 Dec 30. Cell Mol Life Sci. 2016. PMID: 26718486 Free PMC article. Review.
Animal models of frailty: current applications in clinical research.
Kane AE, Hilmer SN, Mach J, Mitchell SJ, de Cabo R, Howlett SE. Kane AE, et al. Among authors: mitchell sj. Clin Interv Aging. 2016 Oct 26;11:1519-1529. doi: 10.2147/CIA.S105714. eCollection 2016. Clin Interv Aging. 2016. PMID: 27822024 Free PMC article. Review.
382 results