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The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir.
Dinh T, Tber Z, Rey JS, Mengshetti S, Annamalai AS, Haney R, Briganti L, Amblard F, Fuchs JR, Cherepanov P, Kim K, Schinazi RF, Perilla JR, Kim B, Kvaratskhelia M. Dinh T, et al. Among authors: briganti l. bioRxiv [Preprint]. 2024 Jan 26:2024.01.26.577387. doi: 10.1101/2024.01.26.577387. bioRxiv. 2024. Update in: mBio. 2024 Oct 15:e0046524. doi: 10.1128/mbio.00465-24. PMID: 38328097 Free PMC article. Updated. Preprint.
Unravelling biochemical and structural features of Bacillus licheniformis GH5 mannanase using site-directed mutagenesis and high-resolution protein crystallography studies.
Briganti L, Manzine LR, de Mello Capetti CC, de Araújo EA, de Oliveira Arnoldi Pellegrini V, Guimaraes FEG, de Oliveira Neto M, Polikarpov I. Briganti L, et al. Int J Biol Macromol. 2024 Aug;274(Pt 2):133182. doi: 10.1016/j.ijbiomac.2024.133182. Epub 2024 Jun 15. Int J Biol Macromol. 2024. PMID: 38885857
Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
Li M, Oliveira Passos D, Shan Z, Smith SJ, Sun Q, Biswas A, Choudhuri I, Strutzenberg TS, Haldane A, Deng N, Li Z, Zhao XZ, Briganti L, Kvaratskhelia M, Burke TR Jr, Levy RM, Hughes SH, Craigie R, Lyumkis D. Li M, et al. Among authors: briganti l. Sci Adv. 2023 Jul 21;9(29):eadg5953. doi: 10.1126/sciadv.adg5953. Epub 2023 Jul 21. Sci Adv. 2023. PMID: 37478179 Free article.
Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection.
Wei G, Iqbal N, Courouble VV, Francis AC, Singh PK, Hudait A, Annamalai AS, Bester S, Huang SW, Shkriabai N, Briganti L, Haney R, KewalRamani VN, Voth GA, Engelman AN, Melikyan GB, Griffin PR, Asturias F, Kvaratskhelia M. Wei G, et al. Among authors: briganti l. Nat Commun. 2022 Oct 6;13(1):5879. doi: 10.1038/s41467-022-33662-6. Nat Commun. 2022. PMID: 36202818 Free PMC article.
23 results