Engelman AN - Search Results

1

The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function.

Singer MR, Dinh T, Levintov L, Annamalai AS, Rey JS, Briganti L, Cook NJ, Pye VE, Taylor IA, Kim K, Engelman AN, Kim B, Perilla JR, Kvaratskhelia M, Cherepanov P. Singer MR, et al. Among authors: engelman an. mBio. 2023 Feb 28;14(1):e0356022. doi: 10.1128/mbio.03560-22. Epub 2023 Feb 6. mBio. 2023. PMID: 36744954 Free PMC article.

2

Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75.

Maertens G, Cherepanov P, Debyser Z, Engelborghs Y, Engelman A. Maertens G, et al. J Biol Chem. 2004 Aug 6;279(32):33421-9. doi: 10.1074/jbc.M404700200. Epub 2004 May 25. J Biol Chem. 2004. PMID: 15163664 Free article.

3

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase.

Cherepanov P, Devroe E, Silver PA, Engelman A. Cherepanov P, et al. J Biol Chem. 2004 Nov 19;279(47):48883-92. doi: 10.1074/jbc.M406307200. Epub 2004 Sep 14. J Biol Chem. 2004. PMID: 15371438 Free article.

4

Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication.

Lu R, Limón A, Devroe E, Silver PA, Cherepanov P, Engelman A. Lu R, et al. J Virol. 2004 Dec;78(23):12735-46. doi: 10.1128/JVI.78.23.12735-12746.2004. J Virol. 2004. PMID: 15542626 Free PMC article.

5

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75.

Cherepanov P, Sun ZY, Rahman S, Maertens G, Wagner G, Engelman A. Cherepanov P, et al. Nat Struct Mol Biol. 2005 Jun;12(6):526-32. doi: 10.1038/nsmb937. Epub 2005 May 15. Nat Struct Mol Biol. 2005. PMID: 15895093

6

Lys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication.

Lu R, Vandegraaff N, Cherepanov P, Engelman A. Lu R, et al. J Virol. 2005 Oct;79(19):12584-91. doi: 10.1128/JVI.79.19.12584-12591.2005. J Virol. 2005. PMID: 16160186 Free PMC article.

7

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

Cherepanov P, Ambrosio AL, Rahman S, Ellenberger T, Engelman A. Cherepanov P, et al. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17308-13. doi: 10.1073/pnas.0506924102. Epub 2005 Oct 31. Proc Natl Acad Sci U S A. 2005. PMID: 16260736 Free PMC article.

8

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo.

Turlure F, Maertens G, Rahman S, Cherepanov P, Engelman A. Turlure F, et al. Nucleic Acids Res. 2006 Mar 20;34(5):1653-65. doi: 10.1093/nar/gkl052. Print 2006. Nucleic Acids Res. 2006. PMID: 16549878 Free PMC article.

9

Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin.

Maertens GN, Cherepanov P, Engelman A. Maertens GN, et al. J Cell Sci. 2006 Jun 15;119(Pt 12):2563-71. doi: 10.1242/jcs.02995. Epub 2006 May 30. J Cell Sci. 2006. PMID: 16735438

10

Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness.

Rahman S, Lu R, Vandegraaff N, Cherepanov P, Engelman A. Rahman S, et al. Virology. 2007 Jan 5;357(1):79-90. doi: 10.1016/j.virol.2006.08.011. Epub 2006 Sep 7. Virology. 2007. PMID: 16959283 Free article.

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