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Tetrazole-based inhibitors of the bacterial enzyme N-succinyl-l,l-2,6-diaminopimelic acid desuccinylase as potential antibiotics.
DiPuma T Jr, Thabthimthong T, Kelley EH, Konczak K, Beulke M, Herbert C, S Habeeb Mohammad T, Starus A, Nocek B, Olsen KW, Holz RC, Becker DP. DiPuma T Jr, et al. Among authors: thabthimthong t. Bioorg Med Chem Lett. 2023 Mar 1;83:129177. doi: 10.1016/j.bmcl.2023.129177. Epub 2023 Feb 9. Bioorg Med Chem Lett. 2023. PMID: 36764468
Biochemical and Structural Analysis of the Bacterial Enzyme Succinyl-Diaminopimelate Desuccinylase (DapE) from Acinetobacter baumannii.
Kelley EH, Minasov G, Konczak K, Shuvalova L, Brunzelle JS, Shukla S, Beulke M, Thabthimthong T, Olsen KW, Inniss NL, Satchell KJF, Becker DP. Kelley EH, et al. Among authors: thabthimthong t. ACS Omega. 2024 Jan 8;9(3):3905-3915. doi: 10.1021/acsomega.3c08231. eCollection 2024 Jan 23. ACS Omega. 2024. PMID: 38284080 Free PMC article.