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Page 1
Tregs constrain CD8+ T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy.
Palmeri JR, Lax BM, Peters JM, Duhamel L, Stinson JA, Santollani L, Lutz EA, Pinney W 3rd, Bryson BD, Wittrup KD. Palmeri JR, et al. bioRxiv [Preprint]. 2023 Feb 1:2023.01.30.526116. doi: 10.1101/2023.01.30.526116. bioRxiv. 2023. Update in: Nat Commun. 2024 Mar 1;15(1):1900. doi: 10.1038/s41467-024-45625-0 PMID: 36778460 Free PMC article. Updated. Preprint.
An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy.
Cowles SC, Sheen A, Santollani L, Lutz EA, Lax BM, Palmeri JR, Freeman GJ, Wittrup KD. Cowles SC, et al. Among authors: palmeri jr. MAbs. 2022 Jan-Dec;14(1):2088454. doi: 10.1080/19420862.2022.2088454. MAbs. 2022. PMID: 35924382 Free PMC article.
Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies.
Lutz EA, Agarwal Y, Momin N, Cowles SC, Palmeri JR, Duong E, Hornet V, Sheen A, Lax BM, Rothschilds AM, Irvine DJ, Spranger S, Wittrup KD. Lutz EA, et al. Among authors: palmeri jr. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2205983119. doi: 10.1073/pnas.2205983119. Epub 2022 Aug 29. Proc Natl Acad Sci U S A. 2022. PMID: 36037341 Free PMC article.
Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies.
Lax BM, Palmeri JR, Lutz EA, Sheen A, Stinson JA, Duhamel L, Santollani L, Kennedy A, Rothschilds AM, Spranger S, Sansom DM, Wittrup KD. Lax BM, et al. Among authors: palmeri jr. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2300895120. doi: 10.1073/pnas.2300895120. Epub 2023 Jul 24. Proc Natl Acad Sci U S A. 2023. PMID: 37487077 Free PMC article.
Local delivery of cell surface-targeted immunocytokines programs systemic anti-tumor immunity.
Santollani L, Zhang YJ, Maiorino L, Palmeri JR, Stinson JA, Duhamel LR, Qureshi K, Suggs JR, Porth OT, Pinney W 3rd, Msari RA, Wittrup KD, Irvine DJ. Santollani L, et al. Among authors: palmeri jr. bioRxiv [Preprint]. 2024 Jan 3:2024.01.03.573641. doi: 10.1101/2024.01.03.573641. bioRxiv. 2024. Update in: Nat Immunol. 2024 Oct;25(10):1820-1829. doi: 10.1038/s41590-024-01925-7 PMID: 38260254 Free PMC article. Updated. Preprint.
Local delivery of cell surface-targeted immunocytokines programs systemic antitumor immunity.
Santollani L, Maiorino L, Zhang YJ, Palmeri JR, Stinson JA, Duhamel LR, Qureshi K, Suggs JR, Porth OT, Pinney W 3rd, Msari RA, Walsh AA, Wittrup KD, Irvine DJ. Santollani L, et al. Among authors: palmeri jr. Nat Immunol. 2024 Oct;25(10):1820-1829. doi: 10.1038/s41590-024-01925-7. Epub 2024 Aug 7. Nat Immunol. 2024. PMID: 39112631 Free PMC article.
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