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Page 1
Catalytic site mutations confer multiple states of G protein activation.
Hewitt N, Ma N, Arang N, Martin SA, Prakash A, DiBerto JF, Knight KM, Ghosh S, Olsen RHJ, Roth BL, Gutkind JS, Vaidehi N, Campbell SL, Dohlman HG. Hewitt N, et al. Sci Signal. 2023 Feb 14;16(772):eabq7842. doi: 10.1126/scisignal.abq7842. Epub 2023 Feb 14. Sci Signal. 2023. PMID: 36787384 Free PMC article.
Molecular annotation of G protein variants in a neurological disorder.
Knight KM, Obarow EG, Wei W, Mani S, Esteller MI, Cui M, Ma N, Martin SA, Brinson E, Hewitt N, Soden GM, Logothetis DE, Vaidehi N, Dohlman HG. Knight KM, et al. Among authors: hewitt n. Cell Rep. 2023 Dec 26;42(12):113462. doi: 10.1016/j.celrep.2023.113462. Epub 2023 Nov 18. Cell Rep. 2023. PMID: 37980565 Free PMC article.
Molecular annotation of G protein variants in a neurological disorder.
Knight KM, Obarow EG, Wei W, Mani S, Esteller MI, Cui M, Ma N, Martin SA, Brinson E, Hewitt N, Soden GM, Logothetis DE, Vaidehi N, Dohlman HG. Knight KM, et al. Among authors: hewitt n. Cell Rep. 2023 Dec 26;42(12):113578. doi: 10.1016/j.celrep.2023.113578. Epub 2023 Dec 2. Cell Rep. 2023. PMID: 38043061 Free PMC article. No abstract available.
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron.
Sloop KW, Cox AL, Wainscott DB, White A, Droz BA, Stutsman C, Showalter AD, Suter TM, Dunbar JD, Snider BM, O'Farrell LS, Hewitt N, Ruble JC, Padgett LR, Woerly EM, Peterson JA, Coskun T, Liu Z, Coutant DE, Ai M, Emmerson PJ, Sangwung P, Willard FS. Sloop KW, et al. Among authors: hewitt n. Sci Transl Med. 2024 Dec 18;16(778):eadp5765. doi: 10.1126/scitranslmed.adp5765. Epub 2024 Dec 18. Sci Transl Med. 2024. PMID: 39693407
In vitro pharmacologic profiling aids systemic toxicity assessment of chemicals.
Burbank M, Kukic P, Ouedraogo G, Kenna JG, Hewitt NJ, Armstrong D, Otto-Bruc A, Ebmeyer J, Boettcher M, Willox I, Mahony C. Burbank M, et al. Among authors: hewitt nj. Toxicol Appl Pharmacol. 2024 Nov;492:117131. doi: 10.1016/j.taap.2024.117131. Epub 2024 Oct 20. Toxicol Appl Pharmacol. 2024. PMID: 39437896 Free article.
176 results