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971 results

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Page 1
Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies.
Painter MM, Johnston TS, Lundgreen KA, Santos JJS, Qin JS, Goel RR, Apostolidis SA, Mathew D, Fulmer B, Williams JC, McKeague ML, Pattekar A, Goode A, Nasta S, Baxter AE, Giles JR, Skelly AN, Felley LE, McLaughlin M, Weaver J; Penn Medicine BioBank; Kuthuru O, Dougherty J, Adamski S, Long S, Kee M, Clendenin C, da Silva Antunes R, Grifoni A, Weiskopf D, Sette A, Huang AC, Rader DJ, Hensley SE, Bates P, Greenplate AR, Wherry EJ. Painter MM, et al. Among authors: rader dj. bioRxiv [Preprint]. 2023 Feb 6:2023.02.05.527215. doi: 10.1101/2023.02.05.527215. bioRxiv. 2023. Update in: Nat Immunol. 2023 Oct;24(10):1711-1724. doi: 10.1038/s41590-023-01613-y PMID: 36798171 Free PMC article. Updated. Preprint.
Sero-monitoring of health care workers reveals complex relationships between common coronavirus antibodies and SARS-CoV-2 severity.
Gouma S, Weirick ME, Bolton MJ, Arevalo CP, Goodwin EC, Anderson EM, McAllister CM, Christensen SR, Dunbar D, Fiore D, Brock A, Weaver J, Millar J, DerOhannessian S; UPenn COVID Processing Unit; Frank I, Rader DJ, Wherry EJ, Hensley SE. Gouma S, et al. Among authors: rader dj. medRxiv [Preprint]. 2021 Apr 19:2021.04.12.21255324. doi: 10.1101/2021.04.12.21255324. medRxiv. 2021. Update in: JCI Insight. 2021 Aug 23;6(16):150449. doi: 10.1172/jci.insight.150449 PMID: 33907765 Free PMC article. Updated. Preprint.
Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.
Zhang C, Verma A, Feng Y, Melo MCR, McQuillan M, Hansen M, Lucas A, Park J, Ranciaro A, Thompson S, Rubel MA, Campbell MC, Beggs W, Hirbo J, Mpoloka SW, Mokone GG; Regeneron Genetic Center; Nyambo T, Meskel DW, Belay G, Fokunang C, Njamnshi AK, Omar SA, Williams SM, Rader D, Ritchie MD, de la Fuente Nunez C, Sirugo G, Tishkoff S. Zhang C, et al. medRxiv [Preprint]. 2021 Aug 7:2021.06.28.21259529. doi: 10.1101/2021.06.28.21259529. medRxiv. 2021. Update in: Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2123000119. doi: 10.1073/pnas.2123000119 PMID: 34230933 Free PMC article. Updated. Preprint.
Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.
Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Rayner NW, Bocher O, Arruda ALSV, Sonehara K, Namba S, Lee SSK, Preuss MH, Petty LE, Schroeder P, Vanderwerff B, Kals M, Bragg F, Lin K, Guo X, Zhang W, Yao J, Kim YJ, Graff M, Takeuchi F, Nano J, Lamri A, Nakatochi M, Moon S, Scott RA, Cook JP, Lee JJ, Pan I, Taliun D, Parra EJ, Chai JF, Bielak LF, Tabara Y, Hai Y, Thorleifsson G, Grarup N, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Kwak SH, Long J, Sun M, Tong L, Chen WM, Nongmaithem SS, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Prins BP, Nicolas A, Yanek LR, Chen G, Brody JA, Kabagambe E, An P, Xiang AH, Choi HS, Cade BE, Tan J, Broadaway KA, Williamson A, Kamali Z, Cui J, Adair LS, Adeyemo A, Aguilar-Salinas CA, Ahluwalia TS, Anand SS, Bertoni A, Bork-Jensen J, Brandslund I, Buchanan TA, Burant CF, Butterworth AS, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Danesh J, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt KU, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Franco OH, Frayling TM, Freedman BI, … See abstract for full author list ➔ Suzuki K, et al. Among authors: rader dj. medRxiv [Preprint]. 2023 Mar 31:2023.03.31.23287839. doi: 10.1101/2023.03.31.23287839. medRxiv. 2023. PMID: 37034649 Free PMC article. Preprint.
Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores.
Abramowitz SA, Boulier K, Keat K, Cardone KM, Shivakumar M, DePaolo J, Judy R, Bermudez F, Mimouni N, Neylan C, Kim D, Rader DJ, Ritchie MD, Voight BF, Pasaniuc B, Levin MG, Damrauer SM; Penn Medicine BioBank. Abramowitz SA, et al. Among authors: rader dj. JAMA. 2024 Nov 16:e2423784. doi: 10.1001/jama.2024.23784. Online ahead of print. JAMA. 2024. PMID: 39549270
Genetic regulation of OAS1 nonsense-mediated decay underlies association with risk of severe COVID-19.
Banday AR, Stanifer ML, Florez-Vargas O, Onabajo OO, Zahoor MA, Papenberg BW, Ring TJ, Lee CH, Andreakos E, Arons E, Barsh G, Biesecker LG, Boyle DL, Burnett-Hartman A, Carrington M, Chang E, Choe PG, Chrisholm RL, Dalgard C, Edberg J, Erdmann N, Feigelson HS, Firestein GS, Gehring AJ, Ho M, Holland S, Hutchinson AA, Im H, Ison MG, Kim HB, Kreitman RJ, Korf BR, Mirabello L, Pacheco JA, Peluso MJ, Rader DJ, Redden DT, Ritchie MD, Rosenbloom B, Sant Anna HP, Savage S, Siouti E, Triantafyllia V, Vargas JM, Verma A, Vij V, Wesemann DR, Yeager M, Yu X, Zhang Y, Boulant S, Chanock SJ, Feld JJ, Prokunina-Olsson L. Banday AR, et al. Among authors: rader dj. medRxiv [Preprint]. 2021 Jul 13:2021.07.09.21260221. doi: 10.1101/2021.07.09.21260221. medRxiv. 2021. Update in: Nat Genet. 2022 Aug;54(8):1103-1116. doi: 10.1038/s41588-022-01113-z PMID: 34282422 Free PMC article. Updated. Preprint.
Comparison of the structure-function properties of wild-type human apoA-V and a C-terminal truncation associated with elevated plasma triglycerides.
Stankov S, Vitali C, Park J, Nguyen D, Mayne L, Englander SW; Regeneron Genetics Center; Levin MG, Vujkovic M, Hand NJ, Phillips MC, Rader DJ. Stankov S, et al. Among authors: rader dj. medRxiv [Preprint]. 2023 Feb 23:2023.02.21.23286268. doi: 10.1101/2023.02.21.23286268. medRxiv. 2023. PMID: 36865344 Free PMC article. Preprint.
Clinical correlates of CT imaging-derived phenotypes among lean and overweight patients with hepatic steatosis.
Song I, Thompson EW, Verma A, MacLean MT, Duda J, Elahi A, Tran R, Raghupathy P, Swago S, Hazim M, Bhattaru A, Schneider C, Vujkovic M, Torigian DA, Kahn CE, Gee JC, Borthakur A, Kripke CM, Carson CC, Carr R, Jehangir Q, Ko YA, Litt H, Rosen M, Mankoff DA, Schnall MD, Shou H, Chirinos J, Damrauer SM, Serper M, Chen J, Rader DJ; Penn Medicine BioBank; Witschey WRT, Sagreiya H. Song I, et al. Among authors: rader dj. Sci Rep. 2024 Jan 2;14(1):53. doi: 10.1038/s41598-023-49470-x. Sci Rep. 2024. PMID: 38167550 Free PMC article.
Facilitating return of actionable genetic research results from a biobank repository: Participant uptake and utilization of digital interventions.
Phung L, Wood E, Egleston B, Hoffman-Andrews L, Ofidis D, Howe S, Mim R, Griffin H, Fetzer D, Owens A, Domchek S, Pyeritz R, Katona B, Kallish S, Sirugo G, Weaver J, Nathanson KL, Rader DJ, Bradbury AR. Phung L, et al. Among authors: rader dj. HGG Adv. 2024 Oct 10;5(4):100346. doi: 10.1016/j.xhgg.2024.100346. Epub 2024 Aug 24. HGG Adv. 2024. PMID: 39183478 Free PMC article. Clinical Trial.
971 results