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A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques.
Tran KM, Kawauchi S, Kramár EA, Rezaie N, Liang HY, Sakr JS, Gomez-Arboledas A, Arreola MA, Cunha CD, Phan J, Wang S, Collins S, Walker A, Shi KX, Neumann J, Filimban G, Shi Z, Milinkeviciute G, Javonillo DI, Tran K, Gantuz M, Forner S, Swarup V, Tenner AJ, LaFerla FM, Wood MA, Mortazavi A, MacGregor GR, Green KN. Tran KM, et al. Among authors: tran k. Mol Neurodegener. 2023 Feb 17;18(1):12. doi: 10.1186/s13024-023-00598-4. Mol Neurodegener. 2023. PMID: 36803190 Free PMC article.
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.
Baglietto-Vargas D, Forner S, Cai L, Martini AC, Trujillo-Estrada L, Swarup V, Nguyen MMT, Do Huynh K, Javonillo DI, Tran KM, Phan J, Jiang S, Kramár EA, Nuñez-Diaz C, Balderrama-Gutierrez G, Garcia F, Childs J, Rodriguez-Ortiz CJ, Garcia-Leon JA, Kitazawa M, Shahnawaz M, Matheos DP, Ma X, Da Cunha C, Walls KC, Ager RR, Soto C, Gutierrez A, Moreno-Gonzalez I, Mortazavi A, Tenner AJ, MacGregor GR, Wood M, Green KN, LaFerla FM. Baglietto-Vargas D, et al. Among authors: tran km. Nat Commun. 2021 Apr 23;12(1):2421. doi: 10.1038/s41467-021-22624-z. Nat Commun. 2021. PMID: 33893290 Free PMC article.
Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer's disease.
Forner S, Kawauchi S, Balderrama-Gutierrez G, Kramár EA, Matheos DP, Phan J, Javonillo DI, Tran KM, Hingco E, da Cunha C, Rezaie N, Alcantara JA, Baglietto-Vargas D, Jansen C, Neumann J, Wood MA, MacGregor GR, Mortazavi A, Tenner AJ, LaFerla FM, Green KN. Forner S, et al. Among authors: tran km. Sci Data. 2021 Oct 15;8(1):270. doi: 10.1038/s41597-021-01054-y. Sci Data. 2021. PMID: 34654824 Free PMC article.
Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease.
Javonillo DI, Tran KM, Phan J, Hingco E, Kramár EA, da Cunha C, Forner S, Kawauchi S, Milinkeviciute G, Gomez-Arboledas A, Neumann J, Banh CE, Huynh M, Matheos DP, Rezaie N, Alcantara JA, Mortazavi A, Wood MA, Tenner AJ, MacGregor GR, Green KN, LaFerla FM. Javonillo DI, et al. Among authors: tran km. Front Neurosci. 2022 Jan 24;15:785276. doi: 10.3389/fnins.2021.785276. eCollection 2021. Front Neurosci. 2022. PMID: 35140584 Free PMC article.
Single cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2R47H Alzheimer's risk gene mutation.
Johnston K, Berackey BB, Tran KM, Gelber A, Yu Z, MacGregor G, Mukamel EA, Tan Z, Green K, Xu X. Johnston K, et al. Among authors: tran km. Res Sq [Preprint]. 2023 Dec 7:rs.3.rs-3656139. doi: 10.21203/rs.3.rs-3656139/v1. Res Sq. 2023. Update in: Mol Psychiatry. 2024 Aug 5. doi: 10.1038/s41380-024-02651-0 PMID: 38106071 Free PMC article. Updated. Preprint.
Genetic diversity promotes resilience in a mouse model of Alzheimer's disease.
Soni N, Hohsfield LA, Tran KM, Kawauchi S, Walker A, Javonillo D, Phan J, Matheos D, Da Cunha C, Uyar A, Milinkeviciute G, Gomez-Arboledas A, Tran K, Kaczorowski CC, Wood MA, Tenner AJ, LaFerla FM, Carter GW, Mortazavi A, Swarup V, MacGregor GR, Green KN. Soni N, et al. Among authors: tran km. Alzheimers Dement. 2024 Apr;20(4):2794-2816. doi: 10.1002/alz.13753. Epub 2024 Mar 1. Alzheimers Dement. 2024. PMID: 38426371 Free PMC article.
APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology.
Tran KM, Kwang N, Gomez-Arboledas A, Kawauchi S, Mar C, Chao D, Da Cunha C, Wang S, Collins S, Walker A, Shi KX, Alcantara JA, Neumann J, Tenner AJ, LaFerla FM, Hohsfield LA, Swarup V, MacGregor GR, Green KN. Tran KM, et al. bioRxiv [Preprint]. 2024 Jun 4:2024.06.03.597211. doi: 10.1101/2024.06.03.597211. bioRxiv. 2024. PMID: 38895362 Free PMC article. Preprint.
[No title available]
[No authors listed] [No authors listed] PMID: 39751248
74 results