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Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties.
Chioua M, Sucunza D, Soriano E, Hadjipavlou-Litina D, Alcázar A, Ayuso I, Oset-Gasque MJ, González MP, Monjas L, Rodríguez-Franco MI, Marco-Contelles J, Samadi A. Chioua M, et al. J Med Chem. 2012 Jan 12;55(1):153-68. doi: 10.1021/jm201105a. Epub 2011 Dec 21. J Med Chem. 2012. PMID: 22126405
Toxicological and pharmacological evaluation, antioxidant, ADMET and molecular modeling of selected racemic chromenotacrines {11-amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ols} for the potential prevention and treatment of Alzheimer's disease.
Oset-Gasque MJ, González MP, Pérez-Peña J, García-Font N, Romero A, del Pino J, Ramos E, Hadjipavlou-Litina D, Soriano E, Chioua M, Samadi A, Raghuvanshi DS, Singh KN, Marco-Contelles J. Oset-Gasque MJ, et al. Eur J Med Chem. 2014 Mar 3;74:491-501. doi: 10.1016/j.ejmech.2013.12.021. Epub 2014 Jan 8. Eur J Med Chem. 2014. PMID: 24502897
CholesteroNitrones for Stroke.
Ayuso MI, Chioua M, Martínez-Alonso E, Soriano E, Montaner J, Masjuán J, Hadjipavlou-Litina DJ, Marco-Contelles J, Alcázar A. Ayuso MI, et al. J Med Chem. 2015 Aug 27;58(16):6704-9. doi: 10.1021/acs.jmedchem.5b00755. Epub 2015 Aug 13. J Med Chem. 2015. PMID: 26241908
New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective ( Z)- N- tert-Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment.
Chioua M, Martínez-Alonso E, Gonzalo-Gobernado R, Ayuso MI, Escobar-Peso A, Infantes L, Hadjipavlou-Litina D, Montoya JJ, Montaner J, Alcázar A, Marco-Contelles J. Chioua M, et al. J Med Chem. 2019 Feb 28;62(4):2184-2201. doi: 10.1021/acs.jmedchem.8b01987. Epub 2019 Feb 15. J Med Chem. 2019. PMID: 30715875
Novel Quinolylnitrones Combining Neuroprotective and Antioxidant Properties.
Chioua M, Salgado-Ramos M, Diez-Iriepa D, Escobar-Peso A, Iriepa I, Hadjipavlou-Litina D, Martínez-Alonso E, Alcázar A, Marco-Contelles J. Chioua M, et al. ACS Chem Neurosci. 2019 Jun 19;10(6):2703-2706. doi: 10.1021/acschemneuro.9b00152. Epub 2019 Apr 9. ACS Chem Neurosci. 2019. PMID: 30943011
222 results