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Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids.
Vidal-Torres A, Fernández-Pastor B, García M, Ayet E, Cabot A, Burgueño J, Monroy X, Aubel B, Codony X, Romero L, Pascual R, Serafini MT, Encina G, Almansa C, Zamanillo D, Merlos M, Vela JM. Vidal-Torres A, et al. Among authors: aubel b. Acta Pharm Sin B. 2023 Jan;13(1):82-99. doi: 10.1016/j.apsb.2022.09.018. Epub 2022 Sep 25. Acta Pharm Sin B. 2023. PMID: 36815042 Free PMC article.
Administration of a co-crystal of tramadol and celecoxib in a 1:1 molecular ratio produces synergistic antinociceptive effects in a postoperative pain model in rats.
Merlos M, Portillo-Salido E, Brenchat A, Aubel B, Buxens J, Fisas A, Codony X, Romero L, Zamanillo D, Vela JM. Merlos M, et al. Among authors: aubel b. Eur J Pharmacol. 2018 Aug 15;833:370-378. doi: 10.1016/j.ejphar.2018.06.022. Epub 2018 Jun 19. Eur J Pharmacol. 2018. PMID: 29932927 Free article.