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Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids.
Vidal-Torres A, Fernández-Pastor B, García M, Ayet E, Cabot A, Burgueño J, Monroy X, Aubel B, Codony X, Romero L, Pascual R, Serafini MT, Encina G, Almansa C, Zamanillo D, Merlos M, Vela JM. Vidal-Torres A, et al. Among authors: codony x. Acta Pharm Sin B. 2023 Jan;13(1):82-99. doi: 10.1016/j.apsb.2022.09.018. Epub 2022 Sep 25. Acta Pharm Sin B. 2023. PMID: 36815042 Free PMC article.
Sigma-1 receptor antagonism as opioid adjuvant strategy: enhancement of opioid antinociception without increasing adverse effects.
Vidal-Torres A, de la Puente B, Rocasalbas M, Touriño C, Bura SA, Fernández-Pastor B, Romero L, Codony X, Zamanillo D, Buschmann H, Merlos M, Baeyens JM, Maldonado R, Vela JM. Vidal-Torres A, et al. Among authors: codony x. Eur J Pharmacol. 2013 Jul 5;711(1-3):63-72. doi: 10.1016/j.ejphar.2013.04.018. Epub 2013 Apr 28. Eur J Pharmacol. 2013. PMID: 23632394
Administration of a co-crystal of tramadol and celecoxib in a 1:1 molecular ratio produces synergistic antinociceptive effects in a postoperative pain model in rats.
Merlos M, Portillo-Salido E, Brenchat A, Aubel B, Buxens J, Fisas A, Codony X, Romero L, Zamanillo D, Vela JM. Merlos M, et al. Among authors: codony x. Eur J Pharmacol. 2018 Aug 15;833:370-378. doi: 10.1016/j.ejphar.2018.06.022. Epub 2018 Jun 19. Eur J Pharmacol. 2018. PMID: 29932927 Free article.
Sigma receptors: biology and therapeutic potential.
Guitart X, Codony X, Monroy X. Guitart X, et al. Among authors: codony x. Psychopharmacology (Berl). 2004 Jul;174(3):301-19. doi: 10.1007/s00213-004-1920-9. Epub 2004 Jun 10. Psychopharmacology (Berl). 2004. PMID: 15197533 Review.
5-HT6 receptor signal transduction second messenger systems.
Codony X, Burgueño J, Ramírez MJ, Vela JM. Codony X, et al. Int Rev Neurobiol. 2010;94:89-110. doi: 10.1016/B978-0-12-384976-2.00004-6. Int Rev Neurobiol. 2010. PMID: 21081203 Review. No abstract available.
Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice.
Langa F, Codony X, Tovar V, Lavado A, Giménez E, Cozar P, Cantero M, Dordal A, Hernández E, Pérez R, Monroy X, Zamanillo D, Guitart X, Montoliu L. Langa F, et al. Among authors: codony x. Eur J Neurosci. 2003 Oct;18(8):2188-96. doi: 10.1046/j.1460-9568.2003.02950.x. Eur J Neurosci. 2003. PMID: 14622179
17 results