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Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids.
Vidal-Torres A, Fernández-Pastor B, García M, Ayet E, Cabot A, Burgueño J, Monroy X, Aubel B, Codony X, Romero L, Pascual R, Serafini MT, Encina G, Almansa C, Zamanillo D, Merlos M, Vela JM. Vidal-Torres A, et al. Among authors: garcia m. Acta Pharm Sin B. 2023 Jan;13(1):82-99. doi: 10.1016/j.apsb.2022.09.018. Epub 2022 Sep 25. Acta Pharm Sin B. 2023. PMID: 36815042 Free PMC article.
Discovery of EST73502, a Dual μ-Opioid Receptor Agonist and σ1 Receptor Antagonist Clinical Candidate for the Treatment of Pain.
García M, Virgili M, Alonso M, Alegret C, Farran J, Fernández B, Bordas M, Pascual R, Burgueño J, Vidal-Torres A, Fernández de Henestrosa AR, Ayet E, Merlos M, Vela JM, Plata-Salamán CR, Almansa C. García M, et al. J Med Chem. 2020 Dec 24;63(24):15508-15526. doi: 10.1021/acs.jmedchem.0c01127. Epub 2020 Oct 16. J Med Chem. 2020. PMID: 33064947
Piperazinyl Bicyclic Derivatives as Selective Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels.
Fernández A, Díaz JL, García M, Rodríguez-Escrich S, Lorente A, Enrech R, Dordal A, Portillo-Salido E, Porras M, Fernández B, Reinoso RF, Vela JM, Almansa C. Fernández A, et al. Among authors: garcia m. ACS Med Chem Lett. 2021 Oct 5;12(11):1802-1809. doi: 10.1021/acsmedchemlett.1c00416. eCollection 2021 Nov 11. ACS Med Chem Lett. 2021. PMID: 34795870 Free PMC article.
EST64454: a Highly Soluble σ1 Receptor Antagonist Clinical Candidate for Pain Management.
Díaz JL, García M, Torrens A, Caamaño AM, Enjo J, Sicre C, Lorente A, Port A, Montero A, Yeste S, Álvarez I, Martín M, Maldonado R, de la Puente B, Vidal-Torres A, Cendán CM, Vela JM, Almansa C. Díaz JL, et al. Among authors: garcia m. J Med Chem. 2020 Dec 10;63(23):14979-14988. doi: 10.1021/acs.jmedchem.0c01575. Epub 2020 Nov 25. J Med Chem. 2020. PMID: 33237785
The 2022 ADEA Climate Study in U.S. and Canadian Dental Schools and Allied Dental Programs: Methodological Considerations.
Inglehart MR, West KP, Stolberg R, Krzanowski S, Smith SG, Lee A, Ester TV, Tucker-Lively FL, Smith CS, Taylor GW, Ware TK, Moran RC, Garcia MN, Hogan RE, Lopez-Fuentes AN, Mitchell DA, Schwartz SB. Inglehart MR, et al. Among authors: garcia mn. J Dent Educ. 2025 Jan 23. doi: 10.1002/jdd.13835. Online ahead of print. J Dent Educ. 2025. PMID: 39844732
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